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By James McFeely, MD
Medical Director, Critical Care Units, Alta Bates Summit Medical Center, Berkeley, CA
Dr. McFeely reports no ﬁnancial relationships relevant to this ﬁeld of study.
The Surviving Sepsis Campaign recently published an update to the 2012 guidelines for management of sepsis and septic shock.1,2 The document incorporates literature published through July 2016. Pediatric guidelines, included in previous documents, have been removed from this version. Although the length of the paper is somewhat intimidating (74 pages, with 93 statements or recommendations regarding sepsis management and 655 references), fortunately for the bedside clinician, recommendations have been enumerated in table form. In addition, there is an accompanying article with recommendations on how this guideline may be approached.3
The panel of experts was divided into five different study sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Professional librarians performed independent literature searches. There was no industry input into guideline development, and no industry representatives were present during any of the deliberations. The 2012 guidelines were reassessed for relevance, and new questions were submitted for inclusion based on research since the last revision.
The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to assess the quality of the information and to determine the strength of recommendations.4 Three levels of statements or recommendations were made: strong (“most patients would accept that intervention and most clinicians should use it in most situations”), weak (“desirable effects of adherence to a recommendation probably will outweigh undesirable effects but with less confidence in these trade-offs”), and best practice statements, which are strong recommendations with unequivocal benefit but where evidence is hard to summarize or access using GRADE methodology.5 Examples of best practice statements include: Treat sepsis as a medical emergency, minimize level of sedation in ventilated patients, and discuss goals of care and prognosis with patients and families.
The campaign goes so far as to state that strong recommendations could be used as quality criteria or performance metric indicators. Several strong recommendations list therapies that are not appropriate for the septic patient. Table 1 lists those interventions not recommended by the current guidelines.
Any references to the three- and six-hour bundles of care have been removed; these are replaced with strong recommendations for rapid administration of fluids (within three hours) and antibiotics (within one hour) and flexible options for dynamic reassessment of adequacy of resuscitation.
One striking recommendation is the strong recommendation for using prone positioning in acute respiratory distress syndrome (ARDS) patients. Tables 2 and 3 list the strong recommendations sorted by section. The bedside clinician would be well-served to review all the tables included in the article, paying particular attention to the strong recommendations in each subsection.
The weak recommendations also are very important, but require more risk/benefit analysis before implementation in any given case. The best practice statements, by and large, appear to be non-controversial, common sense recommendations that most clinicians already should be following.
With this update, the Surviving Sepsis Campaign has done a remarkably good job summarizing the current state of the sepsis literature. It will serve as a reliable reference for bedside providers, administrators, and third-party payers as they develop their performance metrics.
In addition, its robust reference section is a valuable resource for researchers or others who wish to conduct a thorough investigation on any of the specifics recommended in the article.
All ICU clinicians need to review these guidelines, compare them with their current practices, and develop plans for implementation in the near future.
Financial Disclosure: Infectious Disease Alert’s editor, Stan Deresinski, MD, FACP, FIDSA, peer reviewer Patrick Joseph, MD, Updates author Carol A. Kemper, MD, FACP, peer reviewer Kiran Gajurel, MD, executive editor Shelly Morrow Mark, editor Jonathan Springston, and AHC Media editorial group manager Terrey Hatcher report no financial relationships to this field of study.