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The authors of most studies on diagnostic error in the ED use a “look back” approach. Researchers start with the misdiagnosis, then examine the factors associated with it. Other investigators recently used a different method.1
“We took a ‘look forward’ approach in our analysis. We took common symptoms and looked to see the misdiagnoses from these,” says study author Nicole Dubosh, MD. The researchers investigated misdiagnosis of neurological emergencies in the ED for two common complaints: headache and back pain.
“Our methodology is different than many studies about misdiagnosis. It’s a ‘needle and haystack’ phenomenon,” says Jonathan A. Edlow, MD, FACEP, another of the study’s authors.
In this case, the researchers studied the whole “haystack” (for example, all patients presenting with back pain) with the goal of finding only those “needles” (patients with epidural abscess, for instance) who were misdiagnosed in the ED. “Many other papers look only at the pile of needles [only the abscesses], and then see what proportion had been misdiagnosed,” explains Edlow, a professor of emergency medicine at Harvard Medical School and vice chair of the department of emergency medicine at Beth Israel Deaconess Medical Center in Boston.
Researchers analyzed 2,101,081 ED discharges with a nonspecific diagnosis of headache and 1,381,614 ED discharges with a nonspecific diagnosis of back pain. Of all patients with back pain, only a small proportion had an epidural abscess. “Whereas the other type of study methodology may conclude that 30% of epidural abscesses are missed in the ED,” Edlow notes. “The difference in approach is key.”
Using the same “look forward” approach, researchers examined all patients presenting with headache. “Very few have strokes, and only a proportion of these are missed,” Edlow adds.
Dubosh and Edlow did not look at how many of the undiagnosed cases became malpractice claims. However, Edlow says “these cases do tend to have large payouts due to high disability.”
A typical plaintiff in a missed epidural abscess malpractice case: A patient with persistent back pain and bilateral leg radiation, with or without fever, who has a major risk factor (such as IV drug use or a recent bacteremia). The neurological exam is normal, and the patient is diagnosed with simple sciatica. However, the patient returns two days later paraplegic with bladder dysfunction that is permanent.
“Besides the obvious risk factors, sciatica is almost never a bilateral process,” Edlow says. It is also important to know that patients with epidural abscess can go from a normal neurological exam to a serious deficit rapidly due to cord infarction from a septic arteritis or thrombophlebitis, Edlow adds. Some key findings:
• In both populations, male sex, non-Hispanic white, advanced age, and comorbidities (such as HIV/AIDS, malignancy, or neurologic disorders) were associated with higher odds of a bad outcome in both groups.
• Overall, 0.2% of back pain patients and 0.5% of headache patients returned to the ED and were hospitalized for primary diagnosis of a serious neurologic condition or died in hospital within 30 days of ED discharge.
“In terms of percentages, emergency physicians are actually doing a decent job based on our results. However, there is always room for improvement,” says Dubosh, an assistant professor of emergency medicine at Harvard Medical School.
The miss rate was lower than in previous studies. “The surprise was how low the misdiagnosis rate was. However, it is still significant because even though it’s a very small percentage, it’s a very small percentage of a very large number,” Edlow cautions. “The total number of patients affected is important.”
• The most often missed condition for headache was ischemic stroke (18.1%). The most common missed condition for back pain was intraspinal (epidural) abscess (41%).
“More education and awareness is needed on these specific conditions in order to reduce malpractice claims,” Dubosh offers. Edlow says, “The medical/legal implications are tough because there is no magic way to improve this low miss rate.” Knowledge gaps are one known issue.2
Alan Gelb, MD, a professor of emergency medicine at University of California, San Francisco, and chair of the medical risk management committee at Zuckerberg San Francisco General Hospital, commonly sees these three allegations in missed stroke cases:
A recent malpractice case involved an elderly patient who came to the ED with confusion and inability to walk. “It was assumed by the emergency physician to be psychiatric because the patient had a psychiatric history,” Gelb says, noting only a cursory neurologic exam was performed, which was documented as “grossly normal” and “unable to test.”
“The patient had a fairly classic left middle cerebral artery stroke with aphasia and right hemiparesis,” Gelb explains. The patient presented just two hours after onset of symptoms, but because stroke was not diagnosed, no therapy was offered. Aphasia was misunderstood to be psychiatric conversion, depression, or lack of cooperativity. Hemiparesis was not diagnosed because the patient was not following verbal commands because of aphasia.
“The patient was diagnosed the next day as an inpatient, too late for intervention,” Gelb notes.
Financial Disclosure: Kay Ball, PhD, RN, CNOR, FAAN (Nurse Planner), is a consultant for Ethicon USA and Mobile Instrument Service and Repair. The following individuals disclose that they have no consultant, stockholder, speaker’s bureau, research, or other financial relationships with companies having ties to this field of study: Arthur R. Derse, MD, JD, FACEP (Physician Editor), Stacey Kusterbeck (Author), Jonathan Springston (Editor), Jesse Saffron (Editor), Amy M. Johnson, MSN, RN, CPN (Accreditations Manager), and Leslie Coplin (Editorial Group Manager).