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Group A streptococcus (GAS) may cause disease both by direct infection, termed “suppurative disease,” and also by the response of the body to an antecedent infection, termed “nonsuppurative disease.” An invasive GAS infection is defined as one in which GAS can be isolated from a part of the body that is normally sterile, as would be the case in pneumonia but not in pharyngitis.

Pediatric Manifestations of Group A Streptococcal Disease