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MRI analysis of a subset of infants from the Total Body Hypothermia for Neonatal Encephalopathy (TOBY) trial showed that total body hypothermia decreases brain tissue injury in infants with hypoxic-ischemic encephalopathy (HIE).

Therapeutic Hypothermia for Neonatal Hypoxic –Ischemic Encephalopathy: Do Lesions on MRI Predict Outcome?