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The primary purpose of this study was to develop a gene expression profile of BRCA dysfunction ("BRCAness"), which could be used to discriminate sporadic ovarian cancer patients with or without dysfunction to the homologous repair pathway and correlate whether this profile would describe sensitivity to platinum-based chemotherapy and pharmacological inhibition of poly-ADP ribose polymerase (PARP).

BRCAness Correlates with Chemotherapy Responsiveness and Clinical Outcome in Ovarian Cancer