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Knowing when — if ever — is the right time to discontinue antidepression medication is a subject of debate. This article will review the published data on maintenance treatment of depression and the long-term use of antidepressants. Specifically, it will address what currently is known regarding who is an appropriate candidate for long-term therapy; the long-term safety and efficacy data on antidepressants; whether antidepressants may be depressogenic or neuroprotective; and how and when to safely and effectively discontinue the medication.

When Is It Safe to Stop Antidepressants? An Evidence-Based, Patient-Physician Collaborative Approach To Medication Discontinuation