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A formulary switch from levofloxacin to gatifloxacin as the preferred quinolone in a long-term care facility was associated with a significant increase in the incidence of Clostridium difficile-associated diarrhea (CDAD). A case-control study showed that duration of gatifloxacin was independently associated with illness. Switching back to levofloxacin was followed by a decrease in incidence of CDAD to prior levels.

An Outbreak of Clostridium difficile Diarrhea Associated with Gatifloxacin