Supplements for Improving Fertility in Women
Supplements for Improving Fertility in Women
By Dónal P. O’Mathúna, PhD
Lecturer in Health Care Ethics, School of Nursing, Dublin City University, Ireland
Dr. O’Mathúna reports no consultant, stockholder, speaker’s bureau, research, or other financial relationships with companies having ties to this field of study.
Many people eagerly anticipate having children of their own. When the decision is made that the time is right, excitement rises. But as months pass without pregnancy, concerns quickly develop. Fears that one might not be fertile trigger all sorts of emotional reactions. An apparent inability to have a child can impact one’s self-esteem and relationships. Infertility can be an enormously difficult condition to accept. Yet one in every six couples in the United States has difficulty conceiving a child; among couples in their late 30s, difficulties occur in one of every three couples.1 In some areas of Africa, the infertility rate is estimated to be between 30-50%.2
Infertility
The World Health Organization defines infertility as "lack of conception following one year of unprotected sexual intercourse."3 One-third of the difficulties conceiving occur with the woman, one-third occur with the man, and one-third occur with both partners or are of unknown origin.1 Infertility is complicated further by the variety of possible causes. Female infertility can be due to physical abnormalities, hormonal imbalances, psychological factors, or damage from previous illnesses or infections.3 Other lifestyle factors—such as excessive use of tobacco, alcohol, or drugs; a highly stressful life; or waiting until later in life to have children—may impact fertility. With such a variety of influences on infertility, finding the specific cause is complicated. The most frequent diagnosis is unexplained infertility.4
Treating Infertility
Difficulty identifying the cause of infertility makes treatment even harder. Conventional medicine offers a growing array of assisted reproductive technologies. However, many of these carry significant physical, emotional, and ethical difficulties. They are expensive and
generally are not covered by insurance. As a result, many people are using complementary therapies for infertility.
A survey of patients at two infertility clinics in England found that 40% of the women at the private clinic and 23% of the women at the National Health Service clinic used complementary and alternative medicine (CAM)
therapies.5 (See table for a list of the therapies.) Of those who used these therapies, 10% believed CAM had helped the infertility, 13% said CAM helped them psychologically, and 22% said CAM helped them relax. Most were generally skeptical of the therapies they were using.
Several CAM therapies and supplements are widely advertised to help improve fertility. Patients are being inundated with marketing schemes for products with names based on well-known pharmaceutical drugs.6 This points to the importance of examining the evidence available for these supplements and therapies. Although some of these products are marketed to men, the focus here will be on those directed toward women.
Holistic Approach
Given the diversity of causes of infertility, a holistic approach examining lifestyle issues and using therapies that reduce stress and anxiety may be beneficial. Therapies that incorporate exercise also may be helpful. It is important to examine the person’s nutritional status as well as psychological and relationship issues. The multifaceted causes of infertility require a multifaceted approach to treatment.
Chaste Tree Berry
The most popular supplement recommended for improving women’s fertility is chaste tree berry (Vitex agnus-castus), which is a bush native to Mediterranean countries and Asia. The herbal remedy made from an extract of its fruit was used in ancient Greece to treat a variety of gynecological problems. More recently, chaste tree berry has been found to have beneficial effects on some symptoms of premenstrual syndrome (PMS). These trials primarily have been with a German product (Femicur®) and a Swiss product (Ze 440). The participants in these studies had only mild side effects from the products.7
Very few trials have been carried out using chaste tree berry to treat infertility. One uncontrolled study examined the effect of chaste tree berry on PMS.8 During the study involving 1,634 women, 23 became pregnant; 19 of the 23 previously had been unable to become pregnant. One randomized, controlled trial involved 96 women with various fertility disorders who were randomly assigned to receive placebo or a liquid extract containing chaste tree berry and other herbs (Mastodynon).9 Fifteen of those receiving chaste tree berry became pregnant; this was significantly more than those taking placebo. However, one-third of the women dropped out of the study.
A more recent pilot study used a chaste tree berry supplement (FertilityBlend) that also contained green tea extract, L-arginine, vitamins, and minerals.1 Thirty women who unsuccessfully had tried to become pregnant for 6-36 months were assigned randomly to receive the herbal supplement or placebo. At the end of the three-month study, four of the 15 women taking the supplement were pregnant, while none taking placebo were pregnant (P < 0.02). Another woman who continued taking the supplement became pregnant after five months. No significant side effects were noted.
The manufacturer’s web site notes that a follow-up study with FertilityBlend will be published soon.10 The same methodology was used in this follow-up study involving 93 women who had been unable to become pregnant in the previous 6-36 months. After six months, 17 of the 53 women taking the supplement were pregnant while only four of the 40 women taking placebo were pregnant (P < 0.01). No significant side effects were noted. Although the total number of studies is small, this chaste tree berry supplement appears to increase women’s fertility. However, this study has a serious limitation because it included women who had been trying to become pregnant for only 6-12 months. According to the WHO definition, these women may not have had any fertility problems. The published data did not allow examination of the impact of their pregnancy rates on the overall results.
Phytoestrogens
Phytoestrogens are a group of compounds found in a variety of foods. Whole grain cereal, fruits, legumes, and berries are rich in phytoestrogens, while soybeans contain some of their highest concentrations. Although phytoestrogens themselves are not steroids, they are able to produce some of the same actions as the female steroid hormone, estrogen. Public interest in these supplements as natural alternatives to hormone replacement therapy has increased. Researchers are examining their potential in the treatment and prevention of a number of gynecological problems. A randomized, controlled study was conducted with 213 infertile patients undergoing in vitro fertilization (IVF).11 Patients received either 1,500 mg/d phytoestrogens or placebo. The group receiving the supplements had significantly higher implantation rates, pregnancy rates, and delivery rates (all P < 0.05). For example, within the supplement group, 30% of the women had reached week 20 or later in their pregnancy when the study ended, compared to 16% of the placebo group. The miscarriage rate did not differ between the two groups. Although very encouraging, more studies are needed to confirm these results.
Miscellaneous Supplements
Many other herbal remedies have been recommended for the treatment of infertility, but have not been researched scientifically. One ethnographic study found that black South African women used 13 herbs to increase their fertility. However, almost nothing is known about the actual effectiveness or safety of these herbs. A review of CAM therapies used for infertility in Iceland similarly listed a number of herbs for which little or no evidence is available.4 These included red clover, nettle, raspberry leaf, and ladies mantle. In Peru, a plant called maca (Lepidium meyenii) has been consumed by men and women in a variety of ways when pregnancy is desired.12 The plant currently is being grown commercially in Eastern Europe, and animal research is starting to support its traditional use.
Table | ||
Complementary therapy use by patients in two U.K. infertility clinics5 | ||
Complementary therapy | Number of people using | Percent (out of 338 respondents) |
Nutritional advice |
34 |
10.1 |
Conclusion
Women seeking to overcome infertility try a wide variety of supplements and complementary therapies. Many of these are sought for general relaxation and well-being. Among the supplements used to treat infertility, a small number of studies have provided preliminary evidence that chaste tree berry may be beneficial. Phytoestrogens have shown themselves to be beneficial for those pursuing IVF. Both of these supplements have mild side effects. However, for the many other herbs and supplements recommended for female fertility, little or no research is available.
Infertility is a very difficult and emotional condition. Methods to help with relaxation are important. Good nutrition and exercise are crucial. This is inevitably a difficult phase for both members of the relationship, so taking time to nurture and strengthen that relationship is also vital.
References
1. Westphal LM, et al. A nutritional supplement for improving fertility in women: A pilot study. J Reprod Med 2004;49:289-293.
2. Steenkamp V. Traditional herbal remedies used by South African women for gynaecological complaints. J Ethnopharmacol 2003;86:97-108.
3. Donnelly D. Report of the Commission on Assisted Human Reproduction. Dublin, Ireland; 2005. Available at: www.dohc.ie/publications/cahr.html. Accessed April 30, 2005.
4. Veal L. Complementary therapy and infertility: An Icelandic perspective. Complement Ther Nurs Midwifery 1998;4:3-6.
5. Coulson C, Jenkins J. Complementary and alternative medicine utilisation in NHS and private clinic settings: A United Kingdompatients. J Exp Clin Assisted Reprod 2005;2:5. Available at: www.jexpclinassistreprod.com/content/2/1/5. Accessed May 25, 2005.
6. Goldstein I. Evidence-based medicine for clinical decision making in sexual health care management: Role of the Journal of Sexual Medicine. J Sex Med 2004;
1:125-127.
7. Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: Prospective, randomised, placebo controlled study. BMJ 2001; 322:134-137.
8. Loch E-G, et al. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Women’s Health Gend Based Med 2000;9:315-320.
9. Gerhard I, et al. Mastodynon(R) bei weiblicher Sterilitat. Forsch Komplementarmed 1998;5:272-278.
10. Westphal LM, et al. Nutritional supplement improves fertility in women. Available at: www.fertilityblend.com/html/clinical_studies.html. Accessed June 10, 2005.
11. Unfer V, et al. Phytoestrogens may improve the pregnancy rate in in vitro fertilization-embryo transfer cycles: A prospective, controlled, randomized trial. Fertil Steril 2004;82:1509-1513.
12. Valentová K, Ulrichová J. Smallanthus sonchifolius and Lepidium meyenii—prospective Andean crops for the prevention of chronic diseases. Biomed Pap Med Fac Univ Palacky OlomoucCzech Repub 2003;147:119-130.
Lecturer in Health Care Ethics, School of Nursing, Dublin City University, Ireland Dr. OMathúna reports no consultant, stockholder, speakers bureau, research, or other financial relationships with companies having ties to this field of study. Many people eagerly anticipate having children of their own. When the decision is made that the time is right, excitement rises. But as months pass without pregnancy, concerns quickly develop. Fears that one might not be fertile trigger all sorts of emotional reactions. An apparent inability to have a child can impact ones self-esteem and relationships. Infertility can be an enormously difficult condition to accept. Yet one in every six couples in the United States has difficulty conceiving a child; among couples in their late 30s, difficulties occur in one of every three couples.1 In some areas of Africa, the infertility rate is estimated to be between 30-50%.2Subscribe Now for Access
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