Wild-type transthyretin amyloidosis, referred to as “senile” amyloidosis previously, usually occurs in the aging population and affects the peripheral nerves and the heart. Usually, neurological symptoms precede cardiac symptoms.
Neurological symptoms and impairments have been found in one-third of hospitalized patients with COVID-19 from countries that have reported these observations so far. This is a rapidly evolving consequence of SARS-CoV-2 infection.
Neurological issues in children can take a very dramatic but relatively benign form, or can be subtle but representative of serious underlying illness. Differentiating between high- and low-risk presentations can be challenging, but a thorough understanding of pediatric practice guidelines can help emergency department physicians determine the most appropriate ED interventions and eliminate potential injury to a child from either excessive intervention or the sequelae of a missed diagnosis. This monograph will help ED physicians recognize and appropriately treat seizures in children, and provide advice to worried parents about their child’s potential for seizure recurrence. In addition, physicians will learn how to determine which patients require lumbar puncture and understand the risks of brain CT imaging in the pediatric population. It also covers how to know when to emergently or urgently refer children to pediatric neurology.
Aß 42, measured in cerebrospinal fluid, may help determine whether patients have normal or increased cortical Aß deposition. Additionally, abnormal PET 18F-flutemetamol retention levels correlate with disease stage in patients with mild cognitive symptoms.