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Medication poisonings in children; rosuvastatin vs atorvastatin for atherosclerosis; saw palmetto for prostate symptoms; using atypical antipsychotics for off-label indications in adults; and FDA actions.
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Extracorporeal membrane oxygenation is associated with a high mortality and a high incidence of neurological complications including stroke, subarachnoid hemorrhage, and brain death.
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Fibroblast growth factor 21, an important regulator of glucose and lipid metabolism in muscle, is strikingly elevated in the serum of patients with mitochondrial respiratory chain deficiencies.
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Progressive multifocal leukoencephalopathy is a rare complication of immunosupression in patients who undergo organ transplantation, with a high death rate.
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Therapeutic hypothermia after cardiac arrest makes prediction of prognosis more difficult, and neuron-specific enolase measurements add an additional objective test to help determine outcome.
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It has been well recognized that a peak in stroke onset occurs during the early morning hours. This possible circadian periodicity is not well understood, and may in part represent stroke onset earlier during the night that goes unrecognized until the patient arouses.
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Migraine patients show impairment in the processing of global visual features, compared with controls, both between and immediately after an attack. The pattern of ictal-interictal potential as noted on magnetoencephalography studies can characterize different migraine types.
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Sleep-disordered breathing is a significant risk factor for cognitive decline and continuous positive airway pressure (CPAP) therapy may prevent or slow this process.
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Amyloidosis may present with the clinical and electrophysiologic features of chronic inflammatory demyelinating polyneuropathy. Nerve biopsy may be necessary to make an accurate diagnosis.
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Extended-release pramipexole is effective in both early and advanced Parkinson's disease, with a safety and tolerability profile similar to that of immediate-release pramipexole.