Articles Tagged With: bacteremia
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IDWeek 2021: Gram-Negative Bacteremia: Are Follow-Up Blood Cultures Routinely Necessary?
A study of significantly immunocompromised patients with gram-negative bacteremia concluded that the routine use of follow-up blood cultures to document clearance is not warranted.
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Adjunctive Daptomycin Does Not Shorten the Duration of MSSA Bacteremia Compared to Standard-of-Care Therapy
A randomized, double-blind, placebo-controlled clinical trial of adults aged 18 years and older found that adjunctive daptomycin did not shorten the duration of methicillin-susceptible Staphylococcus aureus bacteremia compared to monotherapy with an antistaphylococcal beta-lactam antibiotic. -
Bacteremic Urinary Tract Infection in the Elderly — Sometimes It’s a Guessing Game
In elderly patients with bacteremic urinary tract infection (UTI), symptoms of UTI were present in only one-third of patients, only four-fifths had fever, and just three-fifths had an early diagnosis of UTI. -
Infectious Disease Alert Updates
Fatal ESBL Infection from Fecal Microbiota Transplant; Second Joint Infection When One Prosthetic Gets Infected?
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Outcomes with Daptomycin Plus a β-Lactam Compared to Daptomycin Alone for MRSA Bacteremia
In a retrospective cohort study, investigators found the addition of a β-lactam antibiotic to daptomycin led to less clinical failure (60-day all-cause mortality and/or 60-day recurrence) in patients with methicillin-resistant Staphylococcus aureus bacteremia.
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Monotherapy of Pseudomonas aeruginosa Bacteremia — Which β-Lactam Antibiotic Is Best?
No significant difference in the mortality of patients with Pseudomonas aeruginosa bacteremia was seen regardless of treatment with a carbapenem, ceftazidime, or piperacillin-tazobactam. However, the emergence of resistance occurred significantly more frequently in those treated with a carbapenem — largely related to imipenem use.
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Combination Therapy of MRSA Bacteremia Was Not Beneficial in a Randomized Clinical Trial
In a randomized clinical trial conducted at 27 hospitals in four countries, researchers found that the addition of an antistaphylococcal beta-lactam to vancomycin or daptomycin (99% received vancomycin) did not lead to improved outcomes in MRSA bacteremia. The trial was stopped early because of safety concerns, including a higher risk of acute kidney injury in the combination group.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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Seven Days of Antibiotics Was Noninferior to 14 Days for Gram-Negative Rod Bacteremia
In patients with gram-negative rod bacteremia, patients receiving seven days of antibiotics had similar 90-day mortality, readmission rates, and rates of recurrent bacteremia as patients receiving 14 days of antibiotic.