Articles Tagged With: Epilepsy
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Cannabidiol for Pediatric Seizures
Three months of cannabidiol-enriched cannabis extract decreased mean monthly seizure frequency in children and young adults with refractory epilepsy.
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Cannabidiol: Does It Help in Drug-resistant Epileptic Encephalopathies?
In this double-blind, placebo-controlled trial, the authors investigated the efficacy of adjunctive cannabidiol in a population of severe developmental epileptic encephalopathies and found some efficacy.
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Randomized Trial of Cannabidiol for Medically Refractory Seizures in Dravet Syndrome
In a double-blind study, 120 children and young adults with the Dravet syndrome and medically refractory seizures were assigned randomly to receive either cannabidiol or placebo, as well as their usual antiepileptic drugs/therapies. The primary finding was a significant decrease in convulsive seizure frequency during the 14-week treatment period for patients receiving cannabidiol compared to those receiving placebo.
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Evaluation and Management of Seizures in the Emergency Department
Seizures are a common complaint in both children and adults presenting to the emergency department. Seizures may stop prior to physician evaluation, may be ongoing upon presentation, or may occur after the patient is brought to the ED. Patients may be experiencing a seizure for the first time in their lives or may be suffering from chronic epilepsy.
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Autoimmune Antibodies in Patients with Epilepsy of Unknown Etiology
In this prospective study of patients with epilepsy of unknown origin (including new-onset and established epilepsy), more than 20% of patients were found to have neurological autoantibodies strongly suggesting autoimmune origin of their epilepsy.
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Outcomes After Surgical Treatment of Nonlesional Neocortical Epilepsy
In this study of 109 consecutive patients with medically refractory neocortical epilepsy without MRI-identifiable lesions who underwent focal resection at a single hospital from 1995 to 2005, almost 60% of patients achieved long-term seizure freedom, with anti-epileptic drugs being withdrawn successfully in about a third of these patients.
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First-ever Study of Genome Sequencing in the Common Forms of Epilepsy
In the first study with genome sequencing in the common forms of epilepsy, ultra-rare genetic mutations of known epilepsy genes were over-represented in the epilepsy population, compared to controls.
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Structural and Functional Imaging ‘Phenotypes’ in Refractory Temporal Lobe Epilepsy Patients
Using high-resolution 3-T magnetic resonance imaging, temporal lobe epilepsy-hippocampal sclerosis showed significant preoperative ipsilateral volume loss, T2 hyperintensity, and mean diffusivity increases across all subfields, with the greatest effects seen anteriorly. However, temporal lobe epilepsy-gliosis showed increased volume in the dentate gyrus bilaterally, and more focal and subtle increases in T2 intensity and mean diffusivity.
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Predicting Seizure Recurrence with Routine EEG after First Unprovoked Seizure
The authors systematically reviewed prospective and retrospective studies of adults and children undergoing routine electroencephalography (EEG) after a first unprovoked seizure who were followed for at least 1 year. Using positive likelihood ratios, an adult and child with epileptiform discharges on EEG were estimated to have a 77% and 66% probability, respectively, of recurrent seizures.
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Contraceptive selection for women with epilepsy
Epilepsy is common, affecting 2.2 million Americans, of which approximately half are women of reproductive age.1 The Association of Reproductive Health Professionals has just released a webinar, “Women with Nerve: Providing Reproductive Health Care for Women with Epilepsy,” to help providers review evidence-based information on the subject.