Articles Tagged With: ischemic
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Percutaneous Coronary Intervention vs. Placebo for Stable Angina Patients
In this randomized trial of patients with stable angina and objective evidence of ischemia, percutaneous coronary intervention resulted in a significant reduction in angina compared to a placebo procedure.
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Differentiating MELAS from Bland Ischemic Stroke: Clinicoradiologic Criteria
Stroke symptoms in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) are difficult to diagnose correctly, which leads to missed opportunities to provide MELAS-specific treatment. Delay in diagnosis also complicates efforts to investigate acute treatments for MELAS. Khasminsky et al proposed clinicoradiologic criteria based on a single-center validation study. Although there are methodological limitations, the concepts highlighted by the authors are valuable.
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Endovascular Thrombectomy for Large Ischemic Core Strokes
Endovascular thrombectomy has been rapidly adopted throughout the world for the treatment of patients with acute ischemic stroke and large vessel occlusion. This approach has achieved strong recommendations in stroke guidelines. However, the trials that form the basis of the recommendations have strict imaging recruitment criteria.
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Benefits and Risks of Dual Antiplatelet Therapy After Acute Ischemic Stroke or TIA
Secondary prevention of acute ischemic stroke is continuing to evolve with great interest in the use of dual antiplatelet treatment early in the course. A complicating factor has been the role of the CYP2C19 loss-of-function gene that interferes with the conversion of clopidogrel to its active antiplatelet metabolite.
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Endovascular Thrombectomy with or Without Alteplase? Get With The Guidelines
Since 2015, endovascular thrombectomy with intravenous alteplase has been the standard of care for patients with large vessel occlusion and ischemic stroke. However, since that time, the continuing use of alteplase has been questioned by many practitioners and investigators.
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Does Tranexamic Acid Treatment of Acute Intracerebral Hemorrhage Cause Ischemic Stroke?
Acute spontaneous intracerebral hemorrhage is one of the least treatable forms of stroke. Tranexamic acid now is being studied as a hemostatic agent in spontaneous intracerebral hemorrhage. However, similar to the use of other antifibrinolytic drugs, there is concern that there may be ischemic complications from this treatment, including ischemic stroke.
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Does Tranexamic Acid Treatment of Acute Intracerebral Hemorrhage Cause Ischemic Stroke?
Acute spontaneous intracerebral hemorrhage is one of the least treatable forms of stroke. Tranexamic acid now is being studied as a hemostatic agent in spontaneous intracerebral hemorrhage. However, similar to the use of other antifibrinolytic drugs, there is concern that there may be ischemic complications from this treatment, including ischemic stroke.
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Endovascular Thrombectomy with or Without Alteplase? Get With The Guidelines.
Since 2015, endovascular thrombectomy with intravenous alteplase has been the standard of care for patients with large vessel occlusion and ischemic stroke. However, since that time, the continuing use of alteplase has been questioned by many practitioners and investigators.
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It Is Uncertain if Men and Women Present with Different Symptoms at the Onset of Ischemic Stroke
There have been anecdotal reports and small case series that have suggested women may present with symptoms that are different from men at the onset of ischemic stroke or transient ischemic attacks. These investigators conducted a systematic review to determine if there was a difference in presenting symptoms between men and women.
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Men Are More Likely to Have High-Risk and Dangerous Carotid Artery Plaques than Women
Investigators in the Netherlands investigated the differences between atherosclerotic plaque burden and plaque morphology between men and women who had recent ischemic stroke symptoms and less than 70% ipsilateral carotid artery stenosis.