Articles Tagged With: Neuropathy
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Parsonage-Turner Syndrome: Where’s the Lesion?
SYNOPSIS: This careful analysis of MRI imaging of the brachial plexus in patients with well-defined Parsonage-Turner Syndrome showed that the lesions are in peripheral branches of the brachial plexus and not in the roots or cords.
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Treatment for Autoimmune Small-fiber Neuropathy
The cause of most cases of small-fiber neuropathy is uncertain, but many patients have accompanying autoimmune biomarkers. In a carefully selected group of such patients, intravenous immunoglobulin treatment appears to provide benefit.
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Pain in Anti-MAG Neuropathy
Most patients with anti-MAG neuropathy complain of painful paresthesias or dysesthesias, but unlike diabetic neuropathy, these symptoms are not severe and do not affect quality of life as much as motor weakness.
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Diabetes, HbA1c, and Neuropathy
The hallmark of neuropathy associated with type 2 diabetes is reduction of sensory nerve action potential amplitude and not a reduction in conduction velocity, supporting the hypothesis that hyperglycemia causes axonal dysfunction and injury.
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Capsaicin for Painful Diabetic Peripheral Neuropathy
An 8% capsaicin patch relieves pain and improves sleep in patients with painful diabetic peripheral neuropathy.
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Distinguishing the Neuropathy Associated with MGUS from POEMS
Nerve conduction and electromyography can help differentiate the neuropathy associated with monoclonal gammopathy of undetermined significance (MGUS) from polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS).
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Evaluation of Peripheral Neuropathy in the Diabetic Foot
Among the many types of peripheral neuropathy, diabetic peripheral neuropathy is the most common in the U.S. population. Despite the cause, its progression leads to loss of protective sensation, skin ulcerations, and chronic wounds, which in turn cause soft tissue and bone infections requiring amputation. All of these scenarios depend on the type of glycemic control of the patient, and vary by severity. Prevention, ultimately by understanding the pathophysiology of neuropathy and understanding the biomechanics of gait in relation to the foot, has been proven to significantly decrease morbidity with this disease.
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Peripheral Neuropathy and the Diabetic Foot
This issue discusses the principles of assessing and treating patients with diabetic neuropathy so that problems can be identified and appropriately managed to prevent limb loss.
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Prognosticating Ulnar Neuropathy at the Elbow
In a large retrospective review of treatment outcome for ulnar neuropathy at the elbow, no difference was found in outcomes between any of the various conservative or surgical therapies, but prognosis was determined by the severity of the lesion at time of diagnosis.
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Neuropathy in Myeloma
Peripheral neuropathy is uncommon at presentation in patients with myeloma, and may be complicated by vitamin D deficiency and the neurotoxic effects of chemotherapy.