In a large, cross-sectional, multicenter study in Italy that evaluated factors predictive of sexual dysfunction, vaginal dryness correlated independently and negatively with each Female Sexual Function Index domain.
An individual-participant meta-analysis of prospective studies revealed menopausal hormone therapy associated with an elevation in the risk of breast cancer, with the highest risks associated with daily combined therapy.
Participants from the Women’s Health Initiative study who reported consumption of more than two soft drinks per day showed a higher incidence of hip fracture compared to those consuming no soft drinks.
A large Finnish case-control study suggests that postmenopausal hormone therapy results in a 9-17% increase in the risk of Alzheimer’s disease. However, the small effect size, and likely confounding of use effect, does not provide strong evidence for a causal relationship.
Recommendations for menopausal hormone therapy were widely publicized and adopted following the original publication of the results of the Women’s Health Initiative and affected both initiation and continuation of estrogen therapy through at least 2013.
To inform clinical decision-making, investigators performed an analysis looking at the frequency of postmenopausal bleeding in endometrial cancers and the risk of endometrial cancer among women who have postmenopausal bleeding.