Articles Tagged With: reversal
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Rapid Reversal of Anticoagulation Reduces Mortality from Intracerebral Hemorrhage
Because the numbers of patients with primary intracerebral hemorrhage are far lower than those with ischemic stroke, it has been difficult to accumulate a large enough number of patients to clearly analyze the relationship between the time of the hemorrhage and the time to treatment. We need to answer the important question: Does rapid treatment result in a better outcome?
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Preventing and Reversing Cardiovascular Disease Through Lifestyle Modification
Cardiovascular disease (CVD) is the leading cause of death globally and in the United States. Identifying and targeting cardiovascular risk factors is essential for the prevention and long-term management of CVD. Traditionally, factors for the onset and progression of CVD were thought to be mostly genetic. It is now well established that several of these factors are lifestyle mediated. Behavioral changes significantly influence the interplay between a healthy lifestyle and the genetic risk of heart disease. To further understand the challenges with preventing and reversing CVD, providers need to consider the alarming prevalence of risk factors among the U.S. population.
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Reversal of Oral Anticoagulation in the Emergency Department
This review will describe the physiological components of the clotting cascade, highlight common anticoagulant agents in use, and discuss means of oral anticoagulation reversal.
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Reversal of Direct Oral Anticoagulants
Given the growing use of direct oral anticoagulants, particularly in the elderly population, it is important as an emergency physician to be well versed on the methods of emergent reversal of these agents in the bleeding patient.
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NOACs vs. Warfarin: What Are the Data in Patients With Traumatic Brain Injury and Intracranial Hemorrhage?
A three-year analysis of a prospectively maintained database with traumatic brain injury patients revealed that novel oral anticoagulant use is associated with increased risk of intracranial hemorrhage progression, neurosurgical intervention, and mortality.
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Anticoagulation in the Trauma Patient
The number and variety of anticoagulants have expanded greatly during the past decade. Because of the large number of individuals on anticoagulation for various conditions, anticoagulated patients assuredly will present as trauma patients.
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Oral Anticoagulation Reversal
This review discusses anticoagulant medications and reversal agents.
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Idarucizumab Injection (Praxbind)
The FDA has approved the first reversal agent for a direct oral anticoagulant. Idarucizumab is a humanized monoclonal antibody fragment derived from an IgG1 isotype molecule.