Articles Tagged With: therapy
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Disease-Modifying Therapy After Natalizumab Discontinuation in Patients with Relapsing Multiple Sclerosis
In this retrospective cohort study, the investigators found that, when compared to fingolimod and dimethyl fumarate, ocrelizumab use was associated with significantly lower annualized relapse rate and treatment discontinuation. There were no significant differences in outcomes between fingolimod and dimethyl fumarate use. Ocrelizumab use was associated with a lower rate of disability accumulation when compared to fingolimod.
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Celery Seed-Derived Compound: A Legitimate Neuroprotectant for Acute Ischemic Stroke?
A Phase III double-blind, placebo-controlled, randomized controlled trial suggests that early administration of DL-3-n-butylphthalide, when given adjunctively to thrombolysis or endovascular therapy, improves functional outcomes in patients with acute ischemic stroke. Statistically significant results of well-designed analyses are tantalizing, but confidence in the findings is tempered by a lack of generalizability, an unclear mechanism of action, and trial design irregularities.
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HCV: The Cure Is Here, but Thousands Still Dying
About 2 million people in the United States are living with an infectious disease that has been curable for a decade but remains the leading cause of liver cancer and kills about 15,000 people annually: hepatitis C.
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Ibrexafungerp for Vulvovaginal Candidiasis
A randomized clinical trial compared one day of oral ibrexafungerp with placebo for female patients with vulvovaginal candidiasis (VVC). It found ibrexafungerp to be safe and effective, with mild diarrhea the most common adverse event. Ibrexafungerp differs mechanistically from azoles and appears to be a promising new treatment for VVC.
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Outpatient Management of COVID-19
The COVID-19 pandemic continues to be a major public health concern. The availability of new therapies, as well as their use, continues to be shrouded in confusion. This discussion provides a brief clinical overview of COVID-19, followed by a focus on outpatient management and therapy based on our current understanding and available therapies.
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Unique Challenges for IRBs Evaluating Radiation Oncology Study Protocols
There may be few if any radiation oncology investigators at some institutions, and radiation therapy involves rapidly advancing technology. In light of this, IRBs might lack the necessary expertise to review these studies.
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Antihypertensive Therapy for Mild Chronic Hypertension in Pregnant Women
Antihypertensive treatment of mild chronic hypertension in pregnant women was associated with reduced risk of preeclampsia with severe features, medically indicated preterm birth at < 35 weeks’ gestation, placental abruption, and fetal or neonatal demise compared to no treatment.
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Long COVID: The Winding Road Back
Clinical experts working with healthcare professionals who have acquired long COVID say it can be a hard road returning to work, but rehabilitation models used for other chronic conditions are proving helpful.
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Integrate Youth Violence Prevention into Busy ED Workflow
There is an opportunity to intervene with young patients when they present to the ED for treatment of violence-related injuries. However, much less is known about how facilities can effectively seize this opportunity, considering the often-frantic pace of a busy department.
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Gene and Substrate Therapy for Neurogenetic Disease: A Combined Approach to Treat Mitochondrial Myopathy
A combined adenoviral-mediated gene therapy plus substrate therapy delivered to a mouse model of thymidine kinase 2 (TK2) deficiency, manifested most often as a fatal mitochondrial myopathy in infants and children, rescued TK2 activity and prolonged animal lifespan, thus indicating a promising therapeutic approach for affected patients.