Articles Tagged With: tuberculosis
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Infectious Disease Alert Updates
Screening for Chagas in HIV; It’s Not All About the Cough; Linezolid and Cycloserine in CSF Adequate
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Pediatric Tuberculosis
Mycobacterium tuberculosis (MTB) is a significant challenge to children's health. Barriers exist at multiple levels of the care system for MTB. Early recognition and involvement of MTB specialists is critical to facilitate the best outcome for pediatric patients. The authors provide a thorough review of the current standards for care of these challenging patients.
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Prophylaxis for Tuberculosis in Patients with Myasthenia Gravis
In this observational study from an area with a high rate of endemic tuberculosis (TB), prophylactic treatment of TB was appropriate in those treated with high doses of prednisone and evidence of prior TB infection.
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Elevated Procalcitonin Is Associated with Increased Mortality in Pulmonary Tuberculosis
A single-center, prospective, observational study found that an elevated procalcitonin level was associated with an increased risk of death in patients with pulmonary tuberculosis.
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Rifampin vs. Isoniazid for Latent Tuberculosis
A health system cost comparison showed that four months of rifampin was safer and less expensive than nine months of isoniazid in high-income countries, medium-income countries, and African countries.
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Four Months of Rifampin Is Just as Effective, Safer, and Less Expensive than Nine Months of Isoniazid for Latent Tuberculosis
A health system cost comparison found that four months of rifampin was safer and less expensive than nine months of isoniazid in high-income countries, medium-income countries, and African countries.
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2020 Updated LTBI Treatment Guidelines
A committee recommended three rifamycin-based regimens and two alternate six- or nine-month isoniazid monotherapy regimens for latent tuberculosis infection treatment. They gave priority to shorter-course regimens with similar efficacy, higher rates of completion, and favorable tolerability compared with the former standard nine-month regimen of isoniazid.
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New Tuberculosis Testing Guide Supplements CDC Recommendations
The Centers for Disease Control and Prevention dropped annual tuberculosis screening recommendations for healthcare workers last year, saying the disease continues to decline nationwide and healthcare workers appear to be at no greater risk than the general public. However, there are workers who could be exposed at work or in the community, including those from countries with endemic tuberculosis who can be offered new treatments for latent infection.
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Infectious Disease Alert Updates
Metronidazole Neurotoxicity Is Real; 2020 Updated LTBI Treatment Guidelines; Risks of Hookah Smoking
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Latent Tuberculosis Treatment With Four Months of Rifampin Compared to Nine Months of Isoniazid
In an open-label trial, adults with latent tuberculosis infection were randomized to either four months of treatment with rifampin or nine months of treatment with isoniazid. The four-month rifampin regimen was non-inferior to nine months of isoniazid for prevention of active tuberculosis. It also was associated with a higher treatment completion rate and superior safety.