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In a multicenter, randomized, double-blind, placebo-controlled clinical trial of bevacizumab added to standard temozolomide and radiation therapy for patients with glioblastoma multiforme, progression-free survival but not overall survival was enhanced.
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In a well-controlled retrospective analysis of patients who presented with metastatic colorectal cancer, primary tumor resection was associated with improved overall survival.
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Bevacizumab added to chemotherapy, particularly paclitaxel and cisplatin, was efficacious in all response outcomes (objective response, progression-free survival, and overall survival) without diminution in quality of life or unacceptable toxicity.
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The association between oral contraceptive use and ovarian or breast cancer in BRCA1 or BRCA2 mutation carriers are qualitatively similar to associations reported in the general population. Oral contraceptive pill use is inversely associated with ovarian cancer risk. However, it is also associated with a modest, but not statistically significant, increased risk for breast cancer. The analysis was unable to provide conclusive recommendations as to their use as preventive measures given these and other unmeasured risks. However, oral contraceptive pills appear safe for contraception in this population.
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Synopsis: In this study, women without allergies who consumed peanuts or tree nuts five times or more per month around the time of pregnancy compared to less than one time per month had reduced odds of having children with peanut or tree nut allergies.
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A meta-analysis of 19 studies involving first trimester screening for fetal anomalies has shown that a majority of major structural abnormalities can be diagnosed between 11 and 14 weeks and that even cardiac abnormalities can be identified with ultrasound with reasonable efficiency.
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We now have three options for emergency contraception the copper IUD, oral ulipristal acetate, and oral levonorgestrel. One of the most important considerations in using emergency contraception is the initiation of ongoing regular contraception. The special feature will discuss the opportunities and considerations for use of these three different methods of postcoital contraception.
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The FDA has approved the first nasally administered flu vaccine to be marketed in this country. Medimmunes FluMist is also the first influenza vaccine to use live virus.
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Following radiation therapy, adjuvant extrafascial hysterectomy decreased the risk of relapse for patients with bulky stage IB cervical cancer without improving survival.
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Since the introduction of the 3-weekly CHOP (cyclophosphamide, adriamycin, vincristine, prednisone) chemotherapy 25 years ago, many efforts have been undertaken to improve the efficacy of multicycle polychemotherapy for patients with aggressive lymphoma.