Childhood Cancer
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Parents, IRBs Hold Different Views on Phase I Pediatric Oncology Trials
IRB members are more likely than the public to think the risks outweigh the potential medical benefits. Parents think about the possibility of caring for a child with severe cancer and no treatment alternatives. IRBs ensure trials are ethical and that pediatric subjects are not exposed to excessive risk.
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Incidental Splenic Mass
A 61-year-old female was evaluated for intermittent upper abdominal discomfort. A non-contrast enhanced CT revealed 5x3x4 cm lesion in the spleen that appeared to be cystic. -
Occurrence of Second Malignancies after Treatment for Hodgkin's Lymphoma: Who's at Fault?
Capitalizing on a large cohort of British patients followed after treatment for Hodgkin's lymphoma, the risk of occurrence of second malignancy was assessed in the context of treatment with chemotherapy alone vs treatment with combined chemotherapy and radiation. -
Pharmacology Watch
New recommendations for HPV vaccine; guidelines for treatment of essential tremor; updates on smoking cessation drugs; and FDA actions. -
Clinical Briefs in Primary Care Supplement
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Reduced CNS Metastases in TKI-Treated Renal Cell Carcinoma: Data from a Retrospective Analysis
In an analysis of outcomes for patients treated at M.D. Anderson for metastatic renal cell carcinoma before and since the advent of treatment with tyrosine kinase inhibitors (TKI), the development of brain metastases was shown to be significantly reduced. The authors speculate that TKI treatment is altering the natural history of renal carcinoma. -
Allergy and Brain Tumors: Something to Sneeze At!
There have been reports over the past decade of an interesting inverse association between allergy and glioma. In the current report pooling data from four large cohorts, investigators examined (prediagnostic) immunoglobulin E levels in 169 individuals who were to develop glioma and compared these with levels in 520 matched controls. -
Mammographic Breast Density and Breast Cancer Risk in Postmenopausal Women
A 66-year-old postmenopausal retired teacher went to her primary care physician because she found a lump in her right breast during a routine bath. -
Height and Cancer Risk
From a large cohort of women followed prospectively and with an adjunct meta-analysis of existing evaluable studies, a clearly demonstrated, nearly universal (i.e., across tumor types) incremental increase in cancer incidence was observed with advancing height. -
Pharmacology Watch
Medication poisonings in children; rosuvastatin vs atorvastatin for atherosclerosis; saw palmetto for prostate symptoms; using atypical antipsychotics for off-label indications in adults; and FDA actions.