Clinical Publication
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Identifying High-Risk Cancer Patients Through Appropriate Screening
Less than 20% of average-risk women receive guideline-adherent cervical cancer screening, and guideline-adherent screening was highest for primary HPV testing.
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Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein-ehtl (Altuviiio)
Altuviiio can be prescribed to adults and children with hemophilia A (congenital factor VIII deficiency) for routine prophylaxis to reduce the frequency of bleeding episodes, on-demand treatment and control of bleeding episodes, and perioperative bleeding management.
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Clip Found to Be Safe and Effective for Alleviating Tricuspid Regurgitation
In this randomized trial of tricuspid transcatheter edge-to-edge repair, the intervention was found to be safe and effective at alleviating tricuspid regurgitation. Quality of life scores improved with intervention compared with medical therapy, although death and heart failure hospitalization rates were not significantly different.
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Improving Statin Tolerance in Elderly Patients
In a post-hoc analysis of the RACING trial, researchers found the combination of moderate-intensity statin and ezetimibe therapy vs. high-intensity statin therapy alone in older subjects resulted in similar reductions in cardiovascular events over three years, but fewer adverse effects with the combination therapy.
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Zavegepant Nasal Spray (Zavzpret)
Zavegepant can be prescribed to treat migraine, with or without aura, in adults.
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Double BBB, or Complete AV Block?
The ECG in the figure is from a woman who complained she had been experiencing chest pain for several days. What is the rhythm? Is there complete AV block?
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Moderate-Intensity Exercise OK for Statin Users with Muscle Pain
The go-to drug therapy patients use to lower their bad cholesterol levels can cause muscle pain for some, but researchers found moderate exercise would not exacerbate that pain.
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Insulin Resistance at the Blood-Brain Barrier in Alzheimer’s Disease
Alterations in cerebrovascular insulin receptor isoform levels were associated with Alzheimer’s disease pathology and caused deficits in insulin signaling at the level of the blood-brain barrier.
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Multivitamin-Mineral Supplementation vs. Cocoa Extract for Cognition
Researchers followed participants for three years and determined daily cocoa supplement use was not associated with cognitive enhancement in older adults, whereas a multivitamin supplement was associated with significant cognitive benefits.
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The Connection Between Bereavement, Sleep, and Inflammation
This study of the association of sleep disturbance with more markers of inflammation in widows and widowers compared to controls revealed self-reported sleep disturbances are more strongly correlated with increased markers of inflammation in bereaved individuals.