Clinical Publication
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The Connection Between Bereavement, Sleep, and Inflammation
This study of the association of sleep disturbance with more markers of inflammation in widows and widowers compared to controls revealed self-reported sleep disturbances are more strongly correlated with increased markers of inflammation in bereaved individuals.
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Prosocial vs. Self-Rewarding Behavior and Their Effects on Stress Recovery
Two randomized, controlled studies were created to examine the effects of giving gifts vs. receiving gifts after stressful situations. They both revealed the “giving” group reported recovering from stress faster, showing more happiness, showing less desire, and reporting no significant difference in relaxation compared to the “receiving” group and a control group.
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Healthy Lifestyle Behaviors Linked to Slower Memory Decline
In a population-based, prospective cohort study of 29,000 Chinese adults, researchers found healthy lifestyle was associated with slower memory decline, even in the presence of the apolipoprotein E4 allele.
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Self-Treatment of Recurrent Benign Paroxysmal Positional Vertigo
Using a cell phone-based app, self-treatment of recurrent benign positional paroxysmal vertigo was feasible and effective in most patients.
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Does COVID Vaccination Prevent Car Crashes?
In a large study, lack of COVID vaccination was associated with more incidents of car crash injuries.
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Long-Term Maintenance Therapy After Percutaneous Coronary Intervention
An extended six-year follow-up of the HOST-EXAM study revealed the consistent benefit of the primary endpoint of fewer major cardiovascular events and less bleeding with clopidogrel vs. low-dose aspirin monotherapy in post-percutaneous coronary intervention patients who were on dual antiplatelet therapy for one year.
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Sparsentan Tablets (Filspari)
Sparsentan can be prescribed to alleviate proteinuria in adults with primary immunoglobulin A nephropathy who are at risk of rapid disease progression — generally, a urine protein-to-creatinine ratio 1.5 mg/g or higher.
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When the Aortic Annulus Is Small, Does TAVR Valve Type Matter?
In this propensity-matched analysis of transcatheter aortic valve replacement (TAVR) registry patients with small aortic annuli, the hemodynamic advantage of self-expanding TAVR valves was not associated with better clinical outcomes compared with balloon-expandable valves up to five years.
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Does One Negative Troponin Measurement Rule Out Acute Coronary Syndrome?
Using a common clinical chest pain algorithm plus a point-of-care troponin measurement for low-risk patients, researchers reported significantly lower healthcare costs. Also, this approach did not seem to result in more major adverse cardiovascular events.
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Bleeding Risk with Combination Amiodarone and Direct-Acting Oral Anticoagulants
Among patients with atrial fibrillation who were taking a direct-acting oral anticoagulant, there was a significant association between major bleeding and amiodarone use within 60 days, but no association with amiodarone use longer than 60 days before the bleed.