Complications of Pregnancy
RSSArticles
-
Progesterone: Not a Treatment for Threatened Abortion
Investigators of this well-designed, randomized, controlled trial conclusively demonstrated that progesterone supplementation does not reduce the risk of early pregnancy loss in women who experience first trimester bleeding.
-
Should Antibiotic Prophylaxis Be Used for Surgical Treatment of Early Pregnancy Loss?
In this randomized, controlled trial of more than 3,000 women in developing countries with incomplete or missed abortion at less than 22 weeks’ gestation, antibiotic prophylaxis prior to uterine evacuation reduced infection rates when a strict definition for pelvic infection was used, but not when a more expanded definition was used.
-
Multimodal Stepwise Post-Cesarean Pain Control Reduces Opioid Use
These investigators found that the routine use of acetaminophen alone rather than a combination acetaminophen-opioid significantly reduced overall and daily opioid use. In addition, there was no worse effect on overall pain score or length of stay.
-
Should All Pregnant Women Be Screened for Hepatitis C?
In this cost-effectiveness analysis using Markov modeling, investigators found that universal antenatal screening for hepatitis C was cost-effective, with a mean incremental cost-effectiveness ratio of approximately $3,000 per quality-adjusted life years gained compared to risk-based screening.
-
Staged Preeclampsia Screening in Early Pregnancy
The use of 150 mg of daily aspirin from 11 to 14 weeks through 36 weeks of gestation reduces the rate of early preeclampsia (PE) in approximately 90% of at-risk pregnancies. In addition, aspirin also provides the benefit of reducing the risk of PE < 37 weeks by about 60% and the length of NICU stay by about 70%, primarily by reducing the number of neonates delivered before 32 weeks. What constitutes a high-risk patient and what quantifies patient-specific risks before PE develops remain to be answered.
-
The Effect of Preconception Vitamin D Levels on Live Birth and Pregnancy Loss
This secondary analysis of Effects of Aspirin in Gestation and Reproduction trial found that women with sufficient 25-hydroxyvitamin D levels (≥ 30 ng/mL) were more likely to become pregnant and have a live birth than women with insufficient concentrations of vitamin D.
-
Infertility Therapy Leads to Increased Risk of Severe Maternal Morbidity
Women undergoing infertility treatment, particularly in vitro fertilization, are at higher risk of severe maternal morbidity, but the overall risk remains low.
-
Ultrasound vs. MRI in Diagnosis of Placenta Accreta
The authors of this two-center study found that magnetic resonance is not superior to ultrasound in diagnostic accuracy for placenta accreta spectrum disorders, and its usefulness is tempered particularly by a tendency to falsely upgrade the stage of severity.
-
Should Two-Dose Methotrexate Be the Standard of Care for Ectopic Pregnancy?
In this meta-analysis, the two-dose methotrexate treatment protocol was associated with higher odds of treatment success and a shorter treatment period compared to the single-dose protocol.
-
Low-Dose Aspirin and Preterm Birth
SYNOPSIS: A reanalysis of an earlier randomized clinical trial to assess the ability of low-dose aspirin to prevent preeclampsia has shown that the drug diminishes the risk of spontaneously delivering prior to 34 weeks by about half.