Complications of Pregnancy
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Fetal Fibronectin: Its Role in Threatened Preterm Labor
A recent letter to the editor disputes the conclusion of an earlier study that fetal fibronectin is of little value in threatened preterm labor, despite other studies suggesting that when used in conjunction with cervical length measurements, it can diminish unnecessary hospitalizations appreciably.
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Update on Postpartum Hemorrhage
In the United States, postpartum hemorrhage accounts for 11.4% of maternal deaths, the fourth most common cause after cardiovascular diseases, non-cardiovascular diseases, and infection; worldwide, it is the leading cause of maternal mortality. This feature will discuss the latest treatments for managing postpartum hemorrhage.
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Management of Chronic Hypertension in Pregnancy
Chronic hypertension complicates about 5% of pregnancies and has been associated with higher rates of intrauterine growth restriction (IUGR), stillbirth, and, most importantly, superimposed preeclampsia. Although the condition is far from being solved, there have been some major inroads made into its understanding through contemporary investigation.
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Antenatal Steroids for Very Early PTB
A large European multicenter study has shown that antenatal corticosteroid administration in patients at risk for imminent very early preterm birth (24 to 31 weeks) will decrease perinatal mortality and morbidity substantially, even after only three hours of exposure.
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17 P vs. Vaginal Progesterone
A recent randomized study suggested that vaginal progesterone is at least as good as, and may be superior to, intramuscular 17 alpha-hydroxy progesterone caproate in preventing recurrent preterm birth, but shortcomings in the study indicate that more investigation is needed.
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What Is the Risk of Hemorrhage During Pregnancy for a Woman with Brain Arteriovenous Malformation?
The risk of hemorrhage in a pregnant woman with a brain arteriovenous malformation (AVM) is uncertain and management is controversial.
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Maternal Mortality, Postpartum Hemorrhage, and Tranexamic Acid: The WOMAN Study
A multicenter study involving patients in 193 countries has shown a decrease in maternal mortality in women with postpartum hemorrhage who were given tranexamic acid once the diagnosis was made.
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Abortion for Fetal Anomalies: Trends in Gestational Age
In this retrospective cohort study, the median gestational age at the time of abortion for fetal aneuploidy decreased from 19 weeks in 2004 to 14 weeks in 2014. However, the gestational age at the time of abortion for fetal structural abnormalities remained at ≥ 20 weeks over the study period.
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Embryo Implantation
A recent study tracking embryos after embryo transfer has provided insight into why embryos have a greater tendency to ultimately implant in the lower uterine segment, thereby predisposing patients to a greater risk of placental complications.
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Glucose Screening: The Meaning of a Single Abnormal Value in a 3-hour Glucose Tolerance Test
A recent 25-study meta-analysis has shown that patients having only one elevation in a three-hour glucose tolerance test have similar maternal and fetal outcomes as patients diagnosed to have bona fide gestational diabetes.