Critical Care Alert
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Noninvasive Ventilation in Adult Acute Care: Beyond Clinical Indications
Noninvasive ventilation (NIV) is a commonly used modality in adult acute care. This article examines aspects of NIV that might affect the modality’s success or failure.
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Pressure Support Compared to T-Piece Trial: What Is the Optimal Strategy?
Post-hoc analysis of a multicenter, randomized clinical trial among adults receiving at least 24 hours of mechanical ventilation who were ready for ventilator weaning revealed that the use of pressure support significantly increased the proportion of patients successfully extubated compared to T-piece.
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Management of the Cardiac Surgery Patient
The goal of this review is to provide an evidence-based narrative for the management of post-operative patients who have coronary artery bypass graft surgery and heart valve repair/replacement surgeries.
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COVID-19 Patients Can Be Managed Safely with Noninvasive Respiratory Strategies
In this retrospective chart review of adult patients hospitalized with COVID-19 over a one-month period, the implementation of a noninvasive respiratory protocol that encouraged high-flow nasal cannula, noninvasive mechanical ventilation, and self-proning did not result in any significant increase in mortality.
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In the Setting of Non-COVID ARDS, Improvement in Oxygenation with Proning Predicts Survival
In this retrospective cohort study, improvement in the PaO2/FiO2 (P/F) ratio by 54% was the optimal cutoff to predict those more likely to be alive at 28 days.
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Prone Positioning in Acute Respiratory Distress Syndrome
A review of the potential benefits and uses of prone positioning in patients with acute respiratory distress syndrome
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Patients with Higher Renin Levels May Derive More Benefit from Angiotensin II Treatment
Serum renin concentration in patients with catecholamine-resistant vasodilatory shock may identify those for whom treatment with angiotensin II has improved intensive care unit outcomes.
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Convalescent Plasma Therapy Does Not Affect Time to Clinical Improvement in Patients with Severe and Life-Threatening COVID-19
This was a randomized, open-label, multicenter trial of intravenous convalescent plasma infusion (4 mL/kg to 13 mL/kg) therapy. Convalescent plasma therapy was not associated with improvements in mortality or time to clinical improvement.
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A Review of Current Therapeutics for Severe COVID-19 Pneumonia
The aim of this special feature is to review therapeutic options for hospitalized patients with COVID-19 pneumonia.
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Norepinephrine Infusion Through Peripheral Intravenous Lines: Is it Safe?
In a large perioperative patient population, norepinephrine infusion through peripheral intravenous lines did not result in any significant adverse events. However, the specific patient population, limited duration of infusion, and hospital setting may limit the generalizability of these findings.