Critical Care Topics
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COVID-19 Patients Can Be Managed Safely with Noninvasive Respiratory Strategies
In this retrospective chart review of adult patients hospitalized with COVID-19 over a one-month period, the implementation of a noninvasive respiratory protocol that encouraged high-flow nasal cannula, noninvasive mechanical ventilation, and self-proning did not result in any significant increase in mortality.
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In the Setting of Non-COVID ARDS, Improvement in Oxygenation with Proning Predicts Survival
In this retrospective cohort study, improvement in the PaO2/FiO2 (P/F) ratio by 54% was the optimal cutoff to predict those more likely to be alive at 28 days.
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Prone Positioning in Acute Respiratory Distress Syndrome
A review of the potential benefits and uses of prone positioning in patients with acute respiratory distress syndrome
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Patients with Higher Renin Levels May Derive More Benefit from Angiotensin II Treatment
Serum renin concentration in patients with catecholamine-resistant vasodilatory shock may identify those for whom treatment with angiotensin II has improved intensive care unit outcomes.
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Convalescent Plasma Therapy Does Not Affect Time to Clinical Improvement in Patients with Severe and Life-Threatening COVID-19
This was a randomized, open-label, multicenter trial of intravenous convalescent plasma infusion (4 mL/kg to 13 mL/kg) therapy. Convalescent plasma therapy was not associated with improvements in mortality or time to clinical improvement.
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A Review of Current Therapeutics for Severe COVID-19 Pneumonia
The aim of this special feature is to review therapeutic options for hospitalized patients with COVID-19 pneumonia.
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Norepinephrine Infusion Through Peripheral Intravenous Lines: Is it Safe?
In a large perioperative patient population, norepinephrine infusion through peripheral intravenous lines did not result in any significant adverse events. However, the specific patient population, limited duration of infusion, and hospital setting may limit the generalizability of these findings.
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Do We Really Know the Optimal Oxygen Target in Patients with ARDS?
In the LOCO2 study, a conservative oxygen strategy with SpO2 goals of 88% to 92% was not shown to improve mortality over a liberal oxygen strategy as hypothesized, but rather was found to have a worrisome signal of increased mortality and increased mesenteric ischemia.
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Management of Pulmonary-Renal Syndrome
The role of the intensivist in the management of pulmonary-renal syndrome includes appropriate respiratory support and recognition and management of concurrent infection, hypovolemia, acute anemia, and coagulopathy.
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Targeting 100% or 70% of Enteral Calorie Requirements During Critical Illness Results in Equivalent Outcomes at Six Months
This was a multicenter, blinded, parallel-group, randomized trial of mechanically ventilated critically ill patients. Achieving 100% calorie requirements did not change outcomes at six months when compared to a more modest goal of 70% of predicted calorie requirements.