Critical Care Topics
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First-Pass Success Rate Between Rocuronium and Succinylcholine in Emergent Out-of-Hospital Endotracheal Intubation
This randomized, single-blind, noninferiority trial compared rocuronium and succinylcholine for rapid sequence intubation. Rocuronium was noninferior to succinylcholine with respect to the primary endpoint of first-pass intubation success.
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Improving Sepsis Outcomes: Raising the Bar
In addition to compliance with the sepsis bundles, how can critical care providers revolutionize and individualize sepsis care for optimal results?
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Preventing Post-Extubation Respiratory Failure: Can We Decrease Risk in our High-Risk Populations?
A multicenter, randomized clinical trial of 641 adults deemed ready for weaning after at least 24 hours of mechanical ventilation revealed that the use of high-flow nasal oxygen (HFNO) with noninvasive ventilation immediately after extubation significantly decreased the risk of reintubation compared to HFNO alone in mechanically ventilated patients who were at high risk of extubation failure.
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High-Flow Nasal Cannula Oxygen Therapy in Adult Acute Care
A relatively new modality, high-flow nasal cannula oxygen therapy is used commonly to treat acute respiratory failure.
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Early Data on Remdesivir for Severe COVID-19: A Promising Start?
In this group of patients hospitalized with severe COVID-19, the majority of whom required invasive ventilation, 68% showed clinical improvement after treatment with remdesivir on a compassionate-use basis.
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Anticoagulation Therapy in Patients with Severe COVID-19
In a retrospective study involving 449 patients with severe COVID-19 requiring intensive care unit admission, those patients with a positive sepsis coagulation score or D-dimer greater than 3.0 mcg/mL who received prophylactic doses of low molecular weight heparin exhibited lower 28-day mortality.
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Managing COVID-19 Respiratory Failure: Is There a Perfect Management Strategy?
COVID-19 is a systemic disease that primarily injures the vascular endothelium, causing a unique lung injury in which different management strategies may need to be considered to address the specific physiology of each patient.
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Maximal Lung Recruitment Strategy Does Not Reduce Ventilator-Free Days in the Setting of Acute Respiratory Distress Syndrome
In this randomized trial, daily maximal recruitment trials failed to reduce ventilator-free days in the setting of acute respiratory distress syndrome, but increased the risk of cardiovascular adverse effects.
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Impact of Intensive Care Unit Personnel Decisions and Staffing on Patient Outcomes
Nurses with relatively high autonomy, alongside a dedicated intensive care unit (ICU) clinical pharmacist and 24/7 intensivist coverage, were associated with the lowest hospital mortality, shortest ICU lengths of stay, and shortest mechanical ventilator durations compared to other staffing models.