Critical Care
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Patients with Solid Tumors Admitted with Septic Shock: Outcomes and Mortality Predictors
The presence of metastatic disease, respiratory failure, elevated lactate levels, and poor prior performance scores were independent predictors of mortality in patients with solid tumors admitted with septic shock.
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Does Surviving an ECMO Stay Put Patients at Greater Risk for Mental Health Problems?
Survivors of extracorporeal membrane oxygenation (ECMO) have a modest increase in risk of new mental health diagnoses after discharge compared with intensive care unit survivors who do not undergo ECMO.
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Does Selective Decontamination of the Digestive Tract Reduce In-Hospital Mortality in Critically Ill Adults?
The SuDDICU randomized controlled trial of Australian patients found that selective decontamination of the digestive tract (SDD) did not significantly decrease in-hospital mortality, although the confidence interval around the effect estimate includes a clinically important benefit. In a separate systematic review and meta-analysis that included 32 randomized trials and 24,389 participants, SDD was associated with reduced hospital mortality compared with standard care.
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2022-2023: A Severe Season for Respiratory Syncytial Virus
The 2022-2023 northern hemisphere respiratory syncytial virus (RSV) season began with fury, crowding hospitals and making many young children extremely ill. Meanwhile, advancing research points to potential means of better preventing RSV infection.
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Apixaban for Venous Thromboembolism in Patients with End-Stage Kidney Disease
There is a lower risk of bleeding for those taking apixaban during venous thromboembolism treatment compared to warfarin in patients with end-stage kidney disease.
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Controversy Erupts Over Expansion of Medical Assistance in Dying
Ethical controversy has erupted over Canada’s expansion of eligibility criteria for medical assistance in dying.
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Aggressive Fluid Resuscitation in Acute Pancreatitis Does Not Lead to Improved Outcomes
In this multicenter randomized clinical trial, an early aggressive fluid resuscitation strategy led to an increased incidence of fluid overload without reducing the risk of developing moderately severe or severe acute pancreatitis.
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Bougie Use in Airway Management in the Critically Ill
Despite significant advances in our understanding of airway management and intubation of the critically ill, this common intensive care unit (ICU) procedure remains high-risk.
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Simplifying Anticoagulation: Apixaban for VTE in Patients with End-Stage Kidney Disease
There is a lower risk of bleeding with apixaban during the treatment of venous thromboembolism compared to warfarin in patients with end-stage kidney disease.
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Updates in Stress Ulcer Prophylaxis
The development of esophageal, gastric, and duodenal erosions or ulcers may increase the morbidity and mortality of critically ill patients. Stress ulcer prophylaxis can be administered pharmacologically to prevent gastrointestinal bleeding from the ulcers.