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How Did Paralytic Polio Re-Emerge in the U.S.?

Most outbreaks globally are attributed to vaccine-derived polio, or type 2. Cases of the type 2 form of polio stem from the large-scale, global use of the oral polio vaccine, a solution that contains a live (but weakened) virus.

Smallpox and Monkeypox Vaccine, Live, Non-Replicating (Jynneos)

Jynneos can be administered to prevent smallpox and monkeypox in adults age 18 years and older who are at high risk for contracting the infections.

COVID-19 Rebound

Symptomatic and virologic recrudescence after treatment of patients with COVID-19 with Paxlovid occurs in a tiny percentage of patients and generally is mild and self-limited.

Monkeypox Spread to 29 Non-Endemic Nations Unprecedented

The near-simultaneous emergence of monkeypox in the United States, Europe, and other regions where it rarely is seen has raised questions whether the virus could become endemic beyond West and Central Africa, where it is common.

WHO Updates Guidance on Long-Acting HIV Prophylaxis

International group suggests adding injectable cabotegravir to list of prevention tools.

SARS-CoV-2 as a North American Zoonosis

COVID-19 has become a North American zoonosis endemic in the Northeastern white-tailed deer population. Whether it causes symptomatic infection is unclear, but most infections likely are subclinical, with viral shedding in nasal secretions and feces. Now that infection has become established in this animal group, it likely will spread easily.

Are Boosters Prolonging the Pandemic?

Some people have raised the question of whether booster shots are unethical from a global perspective, and even counterproductive to ending the pandemic because highly mutated variants will continue to arise in unvaccinated patients.

Pediatric Malaria

Malaria is present in all continents except Antarctica and has led to significant human illness and death. Children account for the majority of malaria deaths globally, making malaria a significant contributor to childhood mortality worldwide. Malaria is a mandatory consideration for children with fever who are returned travelers, since the disease process can lead to significant mortality and rapid clinical decline. The authors provide an update and current state of care for malaria in the pediatric population.