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Pesticides and Development of Alzheimer’s Disease — New Evidence

A new case-control study finds that increased levels of dichlorodiphenyldichloroethylene (DDE), which is the metabolite of the pesticide dichlorodiphenyltrichloroethane (DDT), are associated with an increased risk for Alzheimer's disease.

MRI as a Biomarker for Hippocampal Injury in Febrile Status Epilepticus

In this prospective study, the authors use brain imaging criteria to determine whether acute febrile status results in acute hippocampal injury and potentially chronic hippocampal sclerosis.

Stroke Alert: A Review of Current Clinical Stroke Literature

What is the Best Treatment for Cerebral Cavernous Malformations?

Cerebrospinal Fluid ß-Amyloid 42 vs Amyloid PET Imaging in the Diagnosis of Alzheimer’s Disease

Aß 42, measured in cerebrospinal fluid, may help determine whether patients have normal or increased cortical Aß deposition. Additionally, abnormal PET 18F-flutemetamol retention levels correlate with disease stage in patients with mild cognitive symptoms.

Varicella-Zoster Virus and Fingolimod: Much Ado about Not Much?

The risk of varicella-zoster virus infections in patients treated with fingolimod is slightly higher than placebo, but is overall quite low.

Somatic Mutations in Cerebral Cortical Malformations

Targeted high-coverage sequencing for causal somatic mutations in patients with cortical malformations is more sensitive than traditional Sanger and whole-exome sequencing.