Infectious Disease Topics
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Measles-induced Immunomodulation and Impact on Childhood Mortality
Population-level studies in high-resource countries demonstrated that fluctuations in childhood mortality from all infectious diseases are strongly associated with measles infection. The effect is likely attributable to generalized immunomodulation that follows measles infection, with a duration of two to three years.
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Infectious Disease Alert Updates
Surprise! My Kid Has Chlamydia; More on C. diff. Transmission; Staph. aureus Carriage and Moustaches
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Clindamycin vs. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Infections
Five hundred twenty-four children and adults with either cellulitis or abscesses larger than 5 cm (smaller for children) were enrolled in a multisite prospective study of clindamycin vs. trimethoprim-sulfamethoxazole dosed for 10 days. Cure rates did not differ between the treatments, and rates of adverse events were similar in the two groups.
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If they’re so difficult to reprocess, why are duodenoscopes approved for surgery?
With all of the difficulties in cleaning duodenoscopes, and the potential for outbreaks of carbapenem-resistant Enterobacteriaceae, some outpatient surgery managers are questioning why these scopes are approved by the Food and Drug Administration. However, the benefits outweigh the risks, some sources say.
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Infectious Disease Alert Updates
The problem of diagnosing TB in children
How best to treat latent TB?
Transmission risk in smear-negative TB
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Antibiotics for Traveler’s Diarrhea?
Foreign travel is associated with travelers’ diarrhea and the intestinal acquisition of extended-spectrum beta lactamase-producing Enterobacteriaceae, especially when travel is to South Asia. The risk of acquisition of resistant flora was almost doubled when antibiotics were used to treat the episode of diarrhea.
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Ceftolozane/Tazobactam — Formulary Considerations
Information about ceftolozane/tazobactam
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Deworming Is Beneficial in HIV-infected Patients
988 HIV-infected pregnant women receiving ART in sub-Saharan Africa were treated with albendazole in a targeted or non-targeted fashion. Albendazole therapy was associated with favorable changes in hemoglobin levels, CD4 counts, and viral loads, particularly in patients with helminth infections.
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Combination Therapy for Invasive Aspergillosis in Patients with Hematologic Malignancies or Hematopoeitic Cell Transplants
In an evaluation of the primary endpoint, all-cause mortality at 6 weeks, there was no statistically significant difference between treatment with voriconazole alone or in combination with anidulafungin in patients with invasive aspergillosis and hematologic malignancies or hematopoietic stem cell transplants.