Integrative Medicine Alert
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H. pylori Infection: A Warning Sign for Alzheimer’s Dementia
A large nested case-control cohort study of subjects aged 50 years and older found that clinically apparent Helicobacter pylori infection is associated with a moderately increased risk of developing Alzheimer’s disease.
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Quality, not Quantity: Plant-Based Carbs Might Result in Less Weight Gain
This long-term prospective study found that adults on low-carbohydrate diets rich in plant-based and whole grain sources of protein and fat experienced significantly less weight gain than those on other types of low-carbohydrate diets.
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Food as Medicine? Follow the Evidence
In this randomized, controlled study of more than 400 individuals with uncontrolled type 2 diabetes and food insecurity, an intensive intervention offering healthy groceries and educational efforts failed to significantly affect glycemic control but resulted in heightened engagement with preventive healthcare services in the intervention group compared to the control.
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Dyeing to Death: Examining the Risks of Red 40 and High-Fat Diets
This study exploring colorectal cancer development reveals that Allura Red AC (Red 40), a synthetic dye prevalent in many American diets, causes significant deoxyribonucleic acid damage and colonic inflammation in mice, especially when combined with a high-fat diet.
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Identifying Risk Factors for Young-Onset Dementia
In this large, population-based prospective cohort study, the investigators identified 15 risk factors that have strong associations with young-onset dementia. Modifications of these risk factors might delay the onset of, or prevent the development of, young-onset dementia.
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Caring After COVID: Is Brain Impairment After Severe COVID-19 Worse Than Other Diseases?
The authors of this prospective cohort study with matched controls found that long-term brain health following severe COVID-19 hospitalization was impaired but was similar to hospitalization from other severe diseases.
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Sleeping Away Dementia
In this long-term observational study of sleep efficiency in the Framingham Heart Study population, researchers found a strong correlation between a decline in duration of slow-wave sleep during aging and the risk of incident dementia from all causes. However, a direct cause-and-effect relationship cannot be determined from this observational study.
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Examining Microbiome Metabolites and Parkinson’s Disease
A Mendelian randomization study shows that trimethylamine N-oxide (TMAO) and its precursor metabolites are not associated with risk of Parkinson’s disease (PD) but have both positive and negative causal effects on some indicators of PD severity and progression.
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Racing Against Depression and Anxiety: Measuring Running vs. Antidepressant Therapy
This prospective study blending randomization with preference compared a running program with antidepressant therapy in adults with depression or anxiety and showed an improvement in mental health in both arms. However, physical health parameters increased only in the running group.
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Searching for Step Counts: Defining Goals for Daily Exercise
A systematic review and meta-analysis of studies of the association of step counts and cadence with all-cause mortality and cardiovascular events showed the benefits in these outcomes are statistically significant, at about 2,600 steps/day and peak at about 8,000 steps/day. Also, faster step cadence augments these benefits.