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Internal Medicine Alert



  • Effect of Atrial Fibrillation Catheter Ablation on Psychological Well-Being

    A randomized trial of catheter ablation vs. medical therapy for atrial fibrillation (AF) patients has shown that anxiety and depression scores are significantly reduced by catheter ablation and are associated with decreases in AF burden and improved physical symptoms.

  • Identifying Risk Factors for Young-Onset Dementia

    In this large, population-based prospective cohort study, the investigators identified 15 risk factors that have strong associations with young-onset dementia. Modifications of these risk factors might delay the onset of, or prevent the development of, young-onset dementia.

  • Bigeminy and What Else?

    The medical providers in this case were concerned the cause of the bigeminal rhythm in the figure below was sinoatrial block. Do you agree? Are there other things to be concerned about?

  • Bempedoic Acid (Nexletol) and Bempedoic Acid and Ezetimibe (Nexlizet)

    The U.S. Food and Drug Administration is expected to update the indications for bempedoic acid and bempedoic acid/ezetimibe. Esperion has submitted clinical evidence in the form of Cholesterol Lowering via Bempedoic Acid an ACL-inhibiting Regimen (CLEAR) that demonstrated that bempedoic acid was associated with a lower risk of major adverse cardiovascular events compared to placebo. Bempedoic acid and bempedoic acid/ezetimibe are distributed by Esperion as Nexletol and Nexlizet, respectively.

  • Is Screening First-Degree Relatives of Cardiomyopathy Patients Worthwhile?

    An observational study of screening first-degree relatives of patients with dilated cardiomyopathy revealed 14% will show either dilated left ventricles, low left ventricular function, or both. These findings are more common if the relatives have been diagnosed with hypertension or are obese, but their frequency is not altered by sex or race.

  • Long-Term Antiplatelet Therapy After PCI

    The five-year follow-up of patients randomized to clopidogrel vs. aspirin monotherapy beyond one year after percutaneous coronary intervention has shown that clopidogrel is noninferior, but not superior, to aspirin for preventing the combined endpoint of adverse cardiovascular or major bleeding events.

  • Dyeing to Death: Examining the Risks of Red 40 and High-Fat Diets

    This study exploring colorectal cancer development reveals that Allura Red AC (Red 40), a synthetic dye prevalent in many American diets, causes significant deoxyribonucleic acid damage and colonic inflammation in mice, especially when combined with a high-fat diet.

  • Vitamin D and Marine n-3 Fatty Acids Reduce Autoimmune Diseases

    Continued use of vitamin D3 and n-3 fatty acids reduced the incidence of autoimmune diseases such as psoriasis.

  • Birch Triterpenes Topical Gel (Oleogel-S10) (Filsuvez)

    The U.S. Food and Drug Administration has approved a treatment for wounds associated with junctional epidermolysis bullosa and dystrophic epidermolysis bullosa not specific to a particular mutation. Birch triterpene is a botanical drug substance composed of a mixture of pentacyclic triterpenes (e.g., botulin, lupeol, betulinic acid, erythrodiol, and oleanolic acid) formulated as a topical gel.

  • Buprenorphine May Be an Effective Alternative to Full Opioids for Pain in the ICU

    In a small, single-center, retrospective, propensity-matched cohort study examining enteral oxycodone vs. sublingual buprenorphine in a critically ill population, pain control was equivalent, indicating that sublingual buprenorphine may be an effective and appropriate alternative.