Internal Medicine
RSSArticles
-
Risk of Atherosclerotic Coronary Artery Disease in Autoimmune Disorders
A large Danish registry study of patients with autoimmune disease referred for coronary computed tomography angiography compared to those without autoimmune disease has shown that autoimmune disease increases the incidence of atherosclerotic events and that the event rate is influenced by traditional atherosclerotic disease risk factors. These results support aggressive risk factor management in patients with autoimmune disease.
-
COVID-19 Vaccine mRNA Suspension for Injection (Comirnaty, Spikevax)
The Food and Drug Administration has approved and granted emergency use authorization for updated messenger ribonucleic acid (mRNA) COVID-19 vaccines.
-
Are Mineralocorticoid Receptor Antagonists Safe in Heart Failure Patients with Renal Dysfunction?
A post hoc analysis of the RALES and EMPHASIS HF trials has shown that, although treatment of heart failure with reduced left ventricular ejection fraction in patients with mineralocorticoid receptor antagonists can cause a significant deterioration in renal function, the benefits outweigh the adverse effects and should not lead to automatic therapy discontinuation.
-
Out of Africa Again? A New Version of Mpox
A novel mpox clade has emerged in Africa and has the potential for a global epidemic.
-
An ECG in Disguise?
The electrocardiogram (ECG) in the figure was recorded from an older man following a bradycardic and hypotensive episode. What ECG diagnosis is suggested by this tracing?
-
Epinephrine Nasal Spray (Neffy)
The U.S. Food and Drug Administration has approved epinephrine nasal spray for the emergency treatment of allergic reactions, including anaphylaxis. It was granted a fast-track designation and will be distributed by ARS Pharmaceuticals as Neffy.
-
Indications for Reduced-Dose Direct Oral Anticoagulants
A subgroup analysis of the ENGAGE-AF TIMI 48 study of edoxaban 60 mg/day vs. 30 mg/day compared to warfarin in patients with atrial fibrillation of the group 80 years of age or older has shown that 30 mg/day results in less major bleeding without a concomitant increase in stroke risk compared to 60 mg/day or warfarin.
-
Anchoring Alzheimer’s Disease Along an Amyloid Timeline
In 601 individuals from Wisconsin-based cohorts with amyloid-beta and tau positron emission tomography scans, the magnitude and topographical spread of tau pathology increased with longer duration of amyloid-beta positivity, and the cognitive decline was steepest in those with the longest duration of amyloid-beta positivity and elevated entorhinal tau.
-
Sweating for Sleep: Examining Evening Exercise and its Effects on Sleep Duration
This small, randomized crossover trial demonstrates that short, repetitive bouts of early evening exercise lead to an increase in total sleep time compared to prolonged sitting.
-
Sofpironium Topical Gel (Sofdra)
The U.S. Food and Drug Administration has approved a second topical anticholinergic product for the treatment of hyperhidrosis.