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Therapeutic hypothermia after cardiac arrest makes prediction of prognosis more difficult, and neuron-specific enolase measurements add an additional objective test to help determine outcome.
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It has been well recognized that a peak in stroke onset occurs during the early morning hours. This possible circadian periodicity is not well understood, and may in part represent stroke onset earlier during the night that goes unrecognized until the patient arouses.
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Migraine patients show impairment in the processing of global visual features, compared with controls, both between and immediately after an attack. The pattern of ictal-interictal potential as noted on magnetoencephalography studies can characterize different migraine types.
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Measurement of biomarkers, including Ab42 and tau protein in the CSF along with volumetric measurements of the hippocampus, may help in the diagnosis of early or presymptomatic Alzheimer's disease.
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Sleep-disordered breathing is a significant risk factor for cognitive decline and continuous positive airway pressure (CPAP) therapy may prevent or slow this process.
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Amyloidosis may present with the clinical and electrophysiologic features of chronic inflammatory demyelinating polyneuropathy. Nerve biopsy may be necessary to make an accurate diagnosis.
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Evaluation of non-Parkinsonian carriers of the LRRK2 mutation associated with Parkinson's disease supports a model of pre-motor symptomatology, including impaired color discrimination and constipation, that could be related to pathology developing prior to that in the substantia nigra.
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Based on data from the Nurses' Health Study II, the authors report that higher maternal intake of vitamin D during pregnancy may be associated with a lower risk of multiple sclerosis in their children.
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ACEI/ARB therapy for AS; safety alert issued for dronedarone; statins and cancer risk; nesiritide and heart failure; and FDA actions.