Viral Infections
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Severe Monkeypox
The Centers for Disease Control and Prevention has summarized 57 cases of individuals hospitalized with severe monkeypox, most of whom were immunocompromised men and a number of whom had delayed initiation of antiviral therapy.
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Genital Herpes — No Longer Just HSV-2 as HSV-1 Makes its Move
Viral shedding after a first episode of genital herpes simplex virus type 1, which is gradually replacing herpes simplex virus type 2 as the major cause of genital infection, occurred in 12.1% at weeks 8-12 and decreased to 7.1% at the end of one year.
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Infectious Disease Alert Updates
Animal Reservoirs for Human Infection; Novel Rat-Derived HEV Infection in Humans; Household Contamination with Monkeypox
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Increasing Incidence of Stage IV Cervical Cancer
The incidence of stage IV cervical cancer in the United States between 2001 and 2018 increased. Rates were highest among Black women, but the annual rate of increase was highest among white women in the South age 40-44 years.
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Evidence of Clinical Efficacy of Bebtelovimab in COVID-19
In a retrospective study, bebtelovimab demonstrated efficacy similar to Paxlovid in high-risk outpatients with recent onset of COVID-19 who reported mild to moderate symptoms.
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Evidence of Clinical Efficacy of Bebtelovimab in COVID-19
A retrospective study found that bebtelovimab has efficacy similar to that of nirmatrelvir/ritonavir (Paxlovid) in the treatment of high-risk outpatients with recent onset of COVID-19 who have mild to moderate symptoms.
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COVID-19: Beware Remdesivir Resistance
Hogan and colleagues reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in ribonucleic acid (RNA)-dependent RNA polymerase after remdesivir treatment.
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Outbreak of a Potentially More Lethal Ebola Virus
A new outbreak of a more lethal Ebola virus is occurring in Uganda with concern about its exportation.
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Can Maternal COVID-19 Vaccination Protect Newborns?
In this case control study, 537 case infants younger than 6 months of age who were admitted to the hospital with COVID-19 were compared to 512 control infants who were hospitalized for other reasons; 16% of the case infants and 29% of the control infants had been born to mothers who had been fully vaccinated against COVID-19 during the pregnancy. The effectiveness of maternal vaccination against infant hospitalization for COVID-19 was 52% overall, 80% during the Delta variant period, and 38% during the Omicron variant period. Effectiveness increased when the vaccine was received after 20 weeks of pregnancy.
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Antibiotic Resistance: We Were Doing Great and then COVID Happened
After improvement, antimicrobial resistance in the United States significantly increased.