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In the early 2000s, substantial evidenced-based interventions were added to the care of critically ill patients that significantly reduced mortality—including low tidal volume ventilatory support for acute respiratory distress syndrome (ARDS), protocolized sedation with daily awakening, Drotrecogin-alpha for severe sepsis, tight glycemic control, corticosteroids for refractory septic shock and preventative strategies for ventilator associated pneumonia.

Special Feature: Life After ARDS: What Survivors Tell Us