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Although previous studies have suggested that hypocalcemia, a common problem in critical illness, is associated with increased mortality in ICU patients, and correction of hypocalcemia has been advocated to prevent neurologic and cardiovascular complications, the literature is still unclear as to the precise relationship between abnormal calcium levels — both hypo- and hypercalcemia — and ICU outcomes.

Abstract & Commentary: Do Serum Ionized Calcium Levels Matter in the ICU?