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In a retrospective tumor registry (SEER) analysis of outcomes for rectal-cancer patients treated over a 14-year period with either presurgical or postsurgical radiation therapy, the importance of pathological lymph node status was found to be significantly more adverse for patients who had presurgical treatment. These patients define a subgroup for whom aggressive post-surgical treatment would seem warranted.

The Importance of Lymph Node Status After Neoadjuvant Therapy for Rectal Cancer