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Lenalidomide is highly effective for low risk MDS associated with a deletion(5q). Raza and colleagues report on lenalidomide for low to intermediate-1 (int-1) risk MDS who were transfusion dependent but without a deletion(5q). Patients received 10 mg daily of lenalidomide either continuously or 21 out of 28 days. Grade 3 and 4 neutropenia and thrombocytopenia occurred in 25 and 20% respectively. Among the 214 patients, 43% responded of which 26% became transfusion independent and the hemoglobin exceeded 10 g/dL. Lenalidomide is an option for red blood cell transfusion dependent low risk MDS, even in patients without a 5q-deletion.

Lenalidomide Active for Non 5q-Low Risk MDS