Articles Tagged With: Dementia
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P-syn in Nerve Fibers on Skin Biopsy May Help Diagnose Dementia with Lewy Bodies
This study compared 18 subjects diagnosed with dementia with Lewy bodies (DLB), 23 with nonsynucleinopathy dementia, and 25 healthy controls and demonstrated that phosphorylated alpha-synuclein was found only in the skin nerve fibers of DLB subjects, helping distinguish this type of dementia from other types.
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AUGS Consensus Statement: Anticholinergic Medication Use and Cognition in Women With Overactive Bladder
Available evidence has shown significant associations between anticholinergic medication use and increased risk of cognitive impairment. Behavioral therapies for overactive bladder should be first-line treatment. If these treatments fail and pharmacologic treatment is considered, providers should counsel patients on associated risks, prescribe the lowest effective dose, and consider alternative treatments in patients at risk.
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Omega-3 Polyunsaturated Fatty Acid Supplementation and Cognitive Decline
In a randomized, placebo-controlled trial of 1,680 participants aged 70 years or older, there was no significant difference in cognitive decline between any of the intervention groups taking omega-3 polyunsaturated fatty acid supplementation and/or multidomain intervention (physical activity, cognitive training, and nutritional advice) compared to the placebo group. However, exploratory post hoc analyses showed some promise for a protective effect with intervention in certain at-risk subgroups.
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Alzheimer’s Prevention: No Harm in ‘Forgetting’ Vitamin E and/or Selenium
This large-scale study of asymptomatic elderly men reveals no indication that selenium or vitamin E (taken alone or in combination) prevents development of dementia.
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Vascular Risk Factors and Their Role in the Development of Alzheimer’s Disease
This study has found an association between mid-life, but not late-life, vascular risk factors and brain amyloid deposition as imaged on amyloid-labeled PET.
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More Confusion Over Whether HRT Prevents Dementia
A 20-year prospective cohort study from Finland did not provide strong evidence that hormone replacement therapy prevents dementia except among women who self-reported long-term use.
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How Useful is Amyloid PET Imaging in the Diagnosis of Dementia?
In a prospective, observational study in multiple centers in Italy, amyloid PET imaging was shown to be negative in 35% of patients who met clinical criteria for a diagnosis of Alzheimer’s disease.
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Alzheimer’s Disease: What the Primary Care Physician Needs to Know
This article explores current medical approaches to Alzheimer’s dementia, the most common subtype of the known dementias or neurocognitive disorders. Preventive treatment is at the forefront of efforts to defeat this progressively impairing disorder; but to be effective, intervention must start well before symptoms begin. The role of the primary care provider in initiating vigorous and early preventive measures and applying appropriate pharmacologic and non-pharmacologic interventions at each stage of disease progression is reviewed and discussed.
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Calcium Supplementation and Increased Dementia Risk
In this five-year observational study, women who were taking calcium supplementation and who had pre-existing cerebrovascular disease were at higher risk of dementia than women not taking extra calcium.
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Seafood Consumption and Brain Mercury Levels in Older Adults with Dementia
This cross-sectional study of older adults who were part of the Rush Memory and Aging Project demonstrated that moderate seafood consumption was correlated with a decreased level of brain Alzheimer’s disease neuropathology in APOE ε4 carriers. Higher brain levels of mercury were correlated with higher seafood consumption. However, these levels were not correlated with brain neuropathology.