Articles Tagged With: Dementia
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Adiposity Is Related to Cerebrovascular and Brain Volumetry Outcomes
In this prospective longitudinal study investigating the potential mechanistic link between adiposity and vascular cognitive impairment, anthropometric and metabolic hormone adiposity predictors were differentially associated with cerebrovascular and brain volumetry outcomes by sex in older individuals.
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Targeting Fyn Kinase in Alzheimer’s Disease: Another Failed Clinical Trial
In this multicenter Phase IIa clinical trial in mild Alzheimer’s disease dementia, the tyrosine kinase Fyn inhibitor AZD0540 had no significant effects after 52 weeks of treatment.
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Statin Use Moderately Reduces Dementia Risk After Concussions in Older Individuals
In a large population study, concussion in older adults resulted in significantly higher risk for dementia that was modestly reduced among those taking a statin.
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Does Hormone Therapy Increase the Risk of Alzheimer’s Disease?
A large Finnish case-control study suggests that postmenopausal hormone therapy results in a 9-17% increase in the risk of Alzheimer’s disease. However, the small effect size, and likely confounding of use effect, does not provide strong evidence for a causal relationship.
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REM Behavior Disorder, Dementia, and Parkinson’s Disease
In this well-designed prospective cohort study of patients with REM behavior disorder, the investigators reported that 73.5% of patients developed a neurodegenerative disorder after a 12-year follow-up.
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Making Sense of Delirium in the Emergency Department
Delirium is a complex disorder marked by the acute onset of mental status change with an associated fluctuating course. Despite the fact that delirium is a common clinical entity in elderly hospitalized patients, the condition may present in any patient regardless of medical comorbidities. Recognition within the emergency setting is becoming increasingly important, as the diagnosis frequently is missed.
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Thinking Outside of the ‘Alpha-Synuclein Box’: A Critical Role of Tau in Lewy Body Disorders
Neocortical tau pathology was associated with worse antemortem cognition in this large study of Parkinson’s disease dementia and dementia with Lewy bodies. Regional brain variations correlated with specific cognitive domains.
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Caregivers and Mindfulness-Based Stress Reduction Interventions
The authors of a review of randomized, controlled trials found that mindfulness-based stress reduction may reduce short-term anxiety and depressive symptoms in people caring for family members with dementia.
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Effect of Diet on Hippocampal Volume in a Population at Risk for Alzheimer’s Disease
Magnetic resonance imaging of the brain in community-dwelling people (average age of 60 years) found that a long-term, high-quality diet was associated with larger hippocampal volumes after an average interval of 11 years.
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Predicting Future Dementia With Retinal Optical Coherence Tomography
Optical coherence tomography (OCT) is an innovative imaging device that measures thickness of retinal nerve fiber layers and ganglion cells. Thinning of these layers is associated with current and future risk of dementia.