The sheer size of the COVID-19 vaccine clinical trials will enhance prelicensure safety and efficacy evaluation. Many post-market evaluations are in development to bolster existing surveillance for adverse events.
Two-thirds of general medicine patients with pneumonia received excess antibiotic therapy, with 93.2% of the unnecessary duration occurring after hospital discharge. Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.
Evidence on actual legal risks of failing to give antibiotics is lacking. Part of the problem is that both clinicians and patients frequently believe that taking an antibiotic is the safest practice in cases where it is unclear if antibiotics are needed.
Cancer patients undergoing treatment are immunocompromised and at high risk for developing early complications leading to critical illness. Compared to complications encountered with conventional chemotherapy, new-generation immunotherapies pose unique diagnostic challenges because their presentation can be vague and nonspecific or can mimic autoimmune diseases.
Understanding the potential reactions that can occur from cannabis and synthetic cannabinoids can help emergency physicians recognize these effects in patients who may present to the emergency department.