Articles Tagged With: antibiotics
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Clostridioides difficile: Risk Factors for Disease
Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.
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Macrolides During Pregnancy — Behind the Headlines
Despite published concerns, there is no good evidence that macrolide use during pregnancy causes birth defects.
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Clostridioides difficile: Risk Factors for Disease
Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.
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Inappropriately Broad Empiric Antibiotics Are Associated with Higher Mortality in Community-Onset Sepsis
A retrospective cohort study found that broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and was associated with worse outcomes and higher mortality.
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Rate of Medicare Beneficiaries Hospitalized for Sepsis Jumps
Investigators observed a 40% increase between 2012 and 2018.
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Longer Antibiotic Courses for Pneumonia Do Not Improve Outcomes, But Cause More Adverse Effects
Two-thirds of general medicine patients with pneumonia received excess antibiotic therapy, with 93.2% of the unnecessary duration occurring after hospital discharge. Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.
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Antimicrobial Stewardship in Critical Care
Antimicrobial stewardship is the responsibility of everyone involved in the care of critically ill and hospitalized patients. This review discusses some of the key principles and practices of successful antimicrobial stewardship programs, particularly as they relate to critical care.
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C. diff: Colonization and Consequences
Although once thought of almost exclusively as a hospital-acquired condition, Clostridioides difficile has established a presence in the community that means about 10% of incoming patients could be carrying it asymptomatically, a new study finds.
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Seven Days of Antibiotics Was Noninferior to 14 Days for Gram-Negative Rod Bacteremia
In patients with gram-negative rod bacteremia, patients receiving seven days of antibiotics had similar 90-day mortality, readmission rates, and rates of recurrent bacteremia as patients receiving 14 days of antibiotic.
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Human Factors: Drug Stewardship in the Emergency Department
Broadly classified as ergonomics in much of the world, human factors engineering ultimately may lead to changes in practices and behaviors entrenched in healthcare that endanger patients with infections and other harms.