The new plan includes details about stronger and more evidence-based activities that have reduced antibiotic resistance, such as optimizing the use of antibiotics in human and animal health settings, that public health officials can lean on to drive progress.
International travel carries a risk of colonization by antimicrobial-resistant intestinal flora. The use of a quinolone, but not a macrolide, during travel further increases the risk of acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae.
No significant difference in the mortality of patients with Pseudomonas aeruginosa bacteremia was seen regardless of treatment with a carbapenem, ceftazidime, or piperacillin-tazobactam. However, the emergence of resistance occurred significantly more frequently in those treated with a carbapenem — largely related to imipenem use.
Infection with Candida auris resistant to azole antifungals, amphotericin B, and echinocandins was identified in three patients in New York. Resistance to echinocandins was first detected after the patients had received an echinocandin as treatment.
Antimicrobial stewardship is the responsibility of everyone involved in the care of critically ill and hospitalized patients. This review discusses some of the key principles and practices of successful antimicrobial stewardship programs, particularly as they relate to critical care.
Imagine if a common healthcare-associated infection became impossible to treat. The nightmare scenario public health officials are contemplating is that an emerging strain of multidrug-resistant Candida auris will displace treatable strains of Candida, which are already a leading cause of bloodstream infections.