Articles Tagged With: treatment
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Long-Term Treatment of Hereditary Amyloid Neuropathy with Patisiran
Hereditary transthyretin-mediated amyloidosis with polyneuropathy is effectively treated by patisiran, a lipid nanoparticle ribonucleic acid interference that binds to transthyretin (TTR) messenger RNA and inhibits TTR production in the liver, resulting in reduction of the serum TTR concentration. Treatment effect has been sustained during a five-year open-label extension study.
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Oral Moxifloxacin vs. Intravenous Ertapenem Followed by Oral Levofloxacin and Metronidazole for Acute Appendicitis
A randomized controlled clinical trial found that a seven-day course of oral moxifloxacin was not noninferior to two days of intravenous ertapenem followed by five days of levofloxacin and metronidazole in adults with uncomplicated acute appendicitis.
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Elderly Patients with Esophageal Cancers Might Tolerate Multimodal Therapy Well
Some clinicians shy away from complete therapy courses for these patients over concerns about frailty, quality of life.
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Streamlined Lyme Disease Guidelines for Frontline Providers
With the peak period for Lyme disease approaching, new guidelines help clinicians understand when to consider the ailment in patients who present to the ED, how to properly diagnosis a case, and how to treat.
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Prednisone vs. Placebo in Short-Term Prevention of Episodic Cluster Headaches
Prednisone, given at 100 mg for five days and then tapering by 20 mg every three days, is a safe and effective short-term prevention for episodic cluster headaches while waiting for longer-acting preventive agents to be initiated.
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Cognitive Benefit of Rivastigmine in Parkinson’s Disease Dementia with Orthostatic Hypotension
Individuals with Parkinson’s disease dementia and orthostatic hypotension (OH) have more robust cognitive improvement from rivastigmine compared to those without OH. This greater response possibly is mediated by the anti-OH effect of rivastigmine.
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Focused Ultrasound in Parkinson’s Disease: Going Beyond Tremor
In this randomized controlled trial, patients with asymmetric Parkinson’s disease were assigned to noninvasive, focused ultrasound-mediated subthalamotomy or sham procedure. The authors reported improved motor function in the focused ultrasound group, with adverse events including weakness, dyskinesia, and gait disturbances.
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Using Sacubitril/Valsartan to Treat Heart Failure with Preserved Ejection Fraction
An analysis of renal outcomes in the PARAGON-HF trial revealed sacubitril/valsartan slows progression of kidney disease in patients with heart failure with preserved ejection fraction compared to valsartan alone.
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Patients with Higher Renin Levels May Derive More Benefit from Angiotensin II Treatment
Serum renin concentration in patients with catecholamine-resistant vasodilatory shock may identify those for whom treatment with angiotensin II has improved intensive care unit outcomes.
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A Review of Current Therapeutics for Severe COVID-19 Pneumonia
The aim of this special feature is to review therapeutic options for hospitalized patients with COVID-19 pneumonia.