Articles Tagged With: treatment
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Considerations and Concerns with Vitamin C in Sepsis and Septic Shock
Sepsis remains a major healthcare problem associated with significant morbidity and mortality. Roles for hydrocortisone, ascorbic acid (vitamin C), and thiamine (HAT therapy) as potential adjuvants remain controversial.
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Tamoxifen for the Management of Bleeding Irregularities in Contraceptive Implant Users
In this double-blind, randomized controlled trial, etonogestrel implant users with prolonged or frequent menses who took 10 mg of tamoxifen twice daily for seven days as needed for irregular bleeding had an average of 9.8 (95% confidence interval, 4.6-15.0) more consecutive days of amenorrhea over a 90-day period compared to those who took a placebo.
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Assessing and Treating Exacerbations of Chronic Obstructive Pulmonary Disease
People with chronic obstructive pulmonary disease frequently seek care for acute exacerbations, which are associated with significant morbidity and mortality. Therefore, it is crucial for physicians to understand how to assess and treat these patients appropriately.
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A Novel Rifabutin-Containing Combination Regimen Is Effective for Eradicating H. pylori Infection
A Phase III, randomized, controlled trial found a significantly higher eradication rate for H. pylori with a 14-day regimen of rifabutin, amoxicillin, and omeprazole compared to 14 days of amoxicillin and omeprazole.
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Acute Treatment of Pediatric Migraine
Primary headaches, especially migraines, are a common problem for adults and children who present to the emergency department. Migraine headaches have been challenging to diagnose, especially in the pediatric population. -
Workforce Well-Being Takes on Added Significance as COVID-19 Battle Continues
With frontline healthcare workers across the country facing unprecedented burdens, there is ample evidence of stress, anxiety, and other behavioral health concerns. Experts note it is critical for leaders to prioritize workforce well-being, and to facilitate connections to treatment and other forms of support, as needed.
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Mobile Stroke Units: What Is the Best Way to Use Them?
A recent advance in ischemic stroke treatment is the mobile stroke unit, an ambulance outfitted with specialized equipment, computed tomography for brain imaging, and a specialized team with a stroke neurologist available either onboard or via telemedicine. Intravenous thrombolytics can be administered at the scene with the patient on the ambulance.
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Clinical Trials of IL-6 Inhibitors for the Treatment of Neuromyelitis Optica Spectrum Disorders
In a randomized, placebo-controlled trial of neuromyelitis optica spectrum disorder patients, satralizumab monotherapy demonstrated a decrease in relapse rate when compared to placebo. In a randomized, open-label, multicenter trial of tocilizumab vs. azathioprine, treatment with tocilizumab demonstrated a decreased risk of a relapse compared to azathioprine.
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A New Treatment for Recurrent Bacterial Vaginosis?
In this randomized controlled trial of 228 women, Lactobacillus crispatus CTV-05 (Lactin-V) applied vaginally for 11 weeks reduced the incidence of recurrent bacterial vaginosis from 45% in the placebo arm to 30% in the Lactin-V arm.
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COVID-19 and Steroids: Is There a Consensus on the Controversy?
A retrospective, single-center cohort study among 201 adults admitted with COVID-19 pneumonia revealed that risk factors associated with the development of acute respiratory distress syndrome (ARDS) and progression from ARDS to death included older age, neutrophilia, organ dysfunction, and coagulation derangement. Treatment with methylprednisolone may be beneficial for these patients.