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Long-term treatment with aspirin is associated with a progressive diminution in platelet sensitivity to the drug.
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In February, the FDA approved a new monoclonal antibody for the treatment of metastatic colorectal cancer.
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A formulary switch from levofloxacin to gatifloxacin as the preferred quinolone in a long-term care facility was associated with a significant increase in the incidence of Clostridium difficile-associated diarrhea (CDAD). A case-control study showed that duration of gatifloxacin was independently associated with illness. Switching back to levofloxacin was followed by a decrease in incidence of CDAD to prior levels.
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Receipt of vancomycin antedated isolation of MRSA with reduced susceptibility to vancomycin in 25 patients. Fortunately, there are several alternatives to vancomycin for many of these isolates. There are, in addition, a large number of antibiotics in the pipeline with activity against Gram-positive organisms.
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A total of 6.2% of hospital employees were nasal carriers of MRSA, with the rate highest among workers in long-term care (36%). In 4 of 10 families surveyed, family members were colonized by the same MRSA as the employee.
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An antibiotic preparation meant for addition to animal feed was found to be contaminated with antibiotic resistance genes. Fortunately, the genes being used generally encode for resistance mechanisms that are already highly prevalent in gastrointestinal bacteria.
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Beksinska and colleagues from South Africa measured FSH levels in long-term older users of depot-medroxyprogesterone acetate (117 women) and norethindrone enanthate (60 women), long-acting progestin-only methods of contraception.
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Most Americans believe that screening tests for cancer save lives and that it is irresponsible not to undergo recommended periodic screening. The presence of a large market for cancer screening may make Americans vulnerable to unproven and unnecessary testing.
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The loss of heterozygosity in the tumor tissue of carriers coupled with the high frequency of patient and family history of breast and ovarian malignancies suggest that USPC might be part of the manifestation of familial breast-ovarian cancer in Ashkenazi Jews.