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  • Birch Triterpenes Topical Gel (Oleogel-S10) (Filsuvez)

    The U.S. Food and Drug Administration has approved a treatment for wounds associated with junctional epidermolysis bullosa and dystrophic epidermolysis bullosa not specific to a particular mutation. Birch triterpene is a botanical drug substance composed of a mixture of pentacyclic triterpenes (e.g., botulin, lupeol, betulinic acid, erythrodiol, and oleanolic acid) formulated as a topical gel.

  • Buprenorphine May Be an Effective Alternative to Full Opioids for Pain in the ICU

    In a small, single-center, retrospective, propensity-matched cohort study examining enteral oxycodone vs. sublingual buprenorphine in a critically ill population, pain control was equivalent, indicating that sublingual buprenorphine may be an effective and appropriate alternative.

  • Long-Term Follow-Up Confirms Efficacy of Invasive Strategy in Very Old Patients with Non-ST-Elevation ACS

    In this long-term analysis of patients in the After Eighty Study, with a mean age of 85 years and non-ST-elevation acute coronary syndrome, an invasive strategy showed a reduction in a composite endpoint of major adverse cardiovascular events and was associated with a significant improvement in event-free survival compared with a conservative approach.

  • Cumulative Number of Head Strikes Contributes to the Development of CTE

    A recent study evaluated the connection between head impact and chronic traumatic encephalopathy (CTE) in male athletes and found that the total number and severity of head impacts throughout life better predicted CTE than the number of symptomatic concussions.

  • Are You Sitting Down to Read This? You May Want to Stand Up

    A large prospective cohort study demonstrated that prolonged sitting at work increases the risk for all-cause and cardiovascular disease mortality, but even short periods of physical activity throughout the day may help mitigate the negative effects.

  • Identifying and Responding to Potential Cases of Human Trafficking in the Primary Care Setting

    This paper aims to equip the primary care provider with the knowledge and skills to identify and respond effectively to potential cases of human trafficking in a primary care setting. When seeking care, individuals caught up in trafficking are most likely to present to an emergency room or urgent care, but about 40% go to private practices or clinics. An astute primary care provider has a unique opportunity to educate, intervene, or assist a patient at this point, should the individual be looking for this type of intervention.

  • Effect of Atrial Fibrillation Catheter Ablation on Psychological Well-Being

    A randomized trial of catheter ablation vs. medical therapy for atrial fibrillation (AF) patients has shown that anxiety and depression scores are significantly reduced by catheter ablation and are associated with decreases in AF burden and improved physical symptoms.

  • Long-Term Antiplatelet Therapy After PCI

    The five-year follow-up of patients randomized to clopidogrel vs. aspirin monotherapy beyond one year after percutaneous coronary intervention has shown that clopidogrel is noninferior, but not superior, to aspirin for preventing the combined endpoint of adverse cardiovascular or major bleeding events.

  • PFO Closure Review Shows High Proportion of Off-Label Use

    In this retrospective cohort study using administrative data from a U.S. payor source, only 58.6% of patients undergoing patent foramen ovale closure had the procedure done for the approved indication of stroke or systemic embolism. A significant proportion of patients were outside the recommended age range.

  • Do Patients Feel Better After Tricuspid Valve Clipping?

    A further analysis of the quality-of-life parameters in a trial of tricuspid transcatheter edge-to-edge repair (T-TEER) in patients with severe symptomatic tricuspid regurgitation vs. medical therapy alone has shown that T-TEER is associated with significant benefits in physical functioning and quality of life that are sustained for one year and were proportional to the magnitude of regurgitation reduction.