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  • Glymphatic and Lymphatic Functions in Patients with Chronic Migraine

    Patients with chronic migraine have dysfunction of their glymphatic and meningeal lymphatic systems, which may play a role in the pathogenesis of migraine.

  • Comparing Patients with Early vs. Late-Onset Multiple Sclerosis

    A recent retrospective study, combining data from a United Kingdom patient registry with a United Kingdom neuropathology tissue bank, showed that late-onset multiple sclerosis (MS), referring to disease onset after age 50 years, is linked with increased disability and quicker progression compared to MS onset at a younger age, and has distinct pathological features.

  • MRI for the Evaluation of Inflammatory Myopathy

    Magnetic resonance imaging (MRI) of large muscles is an important adjunctive diagnostic test for inflammatory myopathies, in conjunction with serum muscle enzymes and electrophysiology. MRI also can identify the highest-yielding section of muscle to target a muscle biopsy.

  • Timing of Biomarker Changes in Alzheimer’s Disease

    In a longitudinal multicenter, nested case-control study of cognitive normal participants from China, the time courses of key Alzheimer’s disease biomarkers were identified during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease.

  • Post-Traumatic Epilepsy and the Risk of Dementia

    A subset of people with head injury will develop post-traumatic epilepsy (PTE). This prospective cohort study demonstrated a 4.5-fold increased risk of dementia in those with PTE compared to people without head trauma or epilepsy, and that this risk exceeds that observed in people with head trauma or epilepsy alone.

  • Omalizumab Injection (Xolair)

    The U.S. Food and Drug Administration has approved the first medication to help reduce allergic reactions, including anaphylaxis, that may occur after accidental exposure to multiple foods. Omalizumab is a recombinant humanized IgG1k monoclonal antibody that selectively binds to immunoglobulin E (IgE) lowering free serum IgE levels.

  • Is Cannabis Abuse During Pregnancy Associated with Poor Neonatal Outcomes?

    Cannabis use disorder is associated with small but significant increased risks measured in multiple neonatal outcomes.

  • Neuropeptides in Patients with Restless Legs Syndrome

    The diurnal onset of restless legs syndrome (RLS) has been replicated in a mouse model using central instillation of the main melanocortin agonist, α-MSH, which stimulates excessive locomotion and grooming in rodents as well as a state of hyperalgesia. The actions of β-endorphin (β-EDP) oppose those of α-MSH, since β-EDP promotes passivity and analgesia. In this study, these prohormones were measured in plasma and cerebrospinal fluid in patients with RLS and compared to controls. Patients with RLS had elevated levels of α-MSH and lower levels of β-EDP compared to the control group.

  • Effect of Atrial Fibrillation Catheter Ablation on Psychological Well-Being

    A randomized trial of catheter ablation vs. medical therapy for atrial fibrillation (AF) patients has shown that anxiety and depression scores are significantly reduced by catheter ablation and are associated with decreases in AF burden and improved physical symptoms.

  • Identifying Risk Factors for Young-Onset Dementia

    In this large, population-based prospective cohort study, the investigators identified 15 risk factors that have strong associations with young-onset dementia. Modifications of these risk factors might delay the onset of, or prevent the development of, young-onset dementia.