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  • As Uncertainty Looms, More People Request Advance Provision of Mifepristone

    Interest in advance provision of abortion medications mifepristone and misoprostol has increased dramatically in the post-Roe era. It remains popular as a U.S. Supreme Court case looms over whether mifepristone should remain available. Advance provision is one tool to help expand access to the medication.

  • Gestational Diabetes Mellitus: An Update on Care

    Early detection of gestational diabetes mellitus (GDM) allows for the implementation of appropriate interventions to reduce the adverse effects of uncontrolled hyperglycemia, making GDM screening an integral part of prenatal care. However, the question of whether to adopt universal or selective (risk-based) screening for GDM has been a subject of ongoing debate and lacks a clear international consensus.

  • Is Cannabis Abuse During Pregnancy Associated with Poor Neonatal Outcomes?

    Cannabis use disorder is associated with small but significant increased risks measured in multiple neonatal outcomes.

  • Permanent Contraception Regret in the Modern Age

    In this Canadian cross-sectional survey of a convenience sample of 844 patients who had undergone female sterilization, the prevalence of regret was 16%.

  • Pelvic Exams During Annual Gynecologic Visits

    A retrospective chart review of 1,121 patients undergoing annual gynecology exams showed that 1.2% (95% confidence interval [CI], 0.5 to 1.9) of asymptomatic patients had physical exam findings on pelvic exam compared to 32.4% (95% CI, 27.0 to 37.8) of symptomatic patients.

  • Bigeminy and What Else?

    The medical providers in this case were concerned the cause of the bigeminal rhythm in the figure below was sinoatrial block. Do you agree? Are there other things to be concerned about?

  • Bempedoic Acid (Nexletol) and Bempedoic Acid and Ezetimibe (Nexlizet)

    The U.S. Food and Drug Administration is expected to update the indications for bempedoic acid and bempedoic acid/ezetimibe. Esperion has submitted clinical evidence in the form of Cholesterol Lowering via Bempedoic Acid an ACL-inhibiting Regimen (CLEAR) that demonstrated that bempedoic acid was associated with a lower risk of major adverse cardiovascular events compared to placebo. Bempedoic acid and bempedoic acid/ezetimibe are distributed by Esperion as Nexletol and Nexlizet, respectively.

  • Is Screening First-Degree Relatives of Cardiomyopathy Patients Worthwhile?

    An observational study of screening first-degree relatives of patients with dilated cardiomyopathy revealed 14% will show either dilated left ventricles, low left ventricular function, or both. These findings are more common if the relatives have been diagnosed with hypertension or are obese, but their frequency is not altered by sex or race.

  • Long-Term Antiplatelet Therapy After PCI

    The five-year follow-up of patients randomized to clopidogrel vs. aspirin monotherapy beyond one year after percutaneous coronary intervention has shown that clopidogrel is noninferior, but not superior, to aspirin for preventing the combined endpoint of adverse cardiovascular or major bleeding events.

  • Dyeing to Death: Examining the Risks of Red 40 and High-Fat Diets

    This study exploring colorectal cancer development reveals that Allura Red AC (Red 40), a synthetic dye prevalent in many American diets, causes significant deoxyribonucleic acid damage and colonic inflammation in mice, especially when combined with a high-fat diet.