Clinical
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Antithrombotic Treatment for Atrial Fibrillation After Acute Coronary Events
An analysis of the AUGUSTUS trial comparing a P2Y12 inhibitor plus four combinations of double or triple therapy with apixaban, aspirin, and a vitamin K antagonist in patients with atrial fibrillation and a recent acute coronary event or percutaneous coronary intervention has shown that a P2Y12 inhibitor plus apixaban exhibited the lowest rate of major adverse events and major bleeding events.
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A New Technique for Predicting Outcomes in Asymptomatic AS
An international study of patients with moderate or asymptomatic severe aortic stenosis has demonstrated that increased amounts of left ventricular fibrosis, as measured by cardiac magnetic resonance imaging, is associated with worse outcomes.
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Xanomeline and Trospium Chloride Capsules (Cobenfy)
The U.S. Food and Drug Administration has approved the first-in-class muscarinic agonist and antagonists for the treatment of schizophrenia in adults. This is the first antipsychotic drug approved in decades and is unique in that it targets cholinergic receptors — unlike traditional agents, which target dopamine receptors.
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How Does the 12-Lead Help?
You are given the electrocardiogram (ECG) in the figure without the benefit of any history. How would you interpret this tracing? How does the 12-lead ECG help with interpretation of the rhythm?
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Eat Your Fruits and Veggies to Decrease HPV Infection
The authors of a study theorized that the increase in vitamin C and other immunological benefits of a regular diet including dark green vegetables and beans and fruits may reduce inflammation and enhance the immune system response, facilitating clearance of genital human papillomavirus.
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Immediate vs. Delayed Postpartum Long-Acting Reversible Contraception
Administering long-acting reversible contraceptives before hospital discharge reduced pregnancy risk and increased usage at six months, making it an effective option for postpartum contraception.
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Are Deep Contraceptive Implant Removals Predictable?
In this retrospective cohort study of 747 patients undergoing contraceptive implant removal, lower body mass index at insertion, weight gain during use, and longer duration of use were risk factors for deep contraceptive implant removal procedures.
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HPV Vaccination Disparities Among Adult Women in the United States
A longitudinal, cross-sectional cohort study of 113,344 participants demonstrated that lack of health insurance, lack of stable employment, and lower income were significantly associated with decreased human papillomavirus vaccination uptake in women aged 18-47 years residing in the United States.
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Treatment Direction After Unsuccessful Attempts at Smoking Cessation
This randomized trial found that, for patients unable to stop smoking after six weeks of treatment, increasing the dose of either varenicline or combination nicotine replacement therapy (CNRT) or switching from CNRT to varenicline, leads to an increased likelihood of success.
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Blood Biomarker for the Diagnosis of Alzheimer’s Disease
In this population-based study of patients in Sweden with cognitive complaints, mild cognitive impairment, and dementia, the use of blood biomarkers, specifically, phosphorylated tau 217 and amyloid-beta 42/40 ratios, improved the diagnostic accuracy for pathological Alzheimer’s disease in primary care patients as well as patients seen by dementia specialists.